Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
1_MQRDH 6_ TMDYK 11_ ESCPS 16_ VSIPS 21_ SDEHR 26_ EKKKR 31_ FTVYK 36_ VLVSV 41_ GRSEW 46_ FVFRR 51_ YAEFD 56_ KLYNT 61_ LKKQF 66_ PAMAL 71_ KIPAK 76_ RIFGD 81_ NFDPD 86_ FIKQR 91_ RAGLN 96_ EFIQN 101_ LVRYP 106_ ELYNH 111_ PDVRA 116_ FLQMD 121_ SPKHQ 126_ SDPSE 131_ DEDER 136_ SSQKL 141_ HSTSQ 146_ NINLG 151_ PSGNP 156_ HAKPT 161_ DFDFL 166_ KVIGK 171_ GSFGK 176_ VLLAK 181_ RKLDG 186_ KFYAV 191_ KVLQK 196_ KIVLN 201_ RKEQK 206_ HIMAE 211_ RNVLL 216_ KNVKH 221_ PFLVG 226_ LHYSF 231_ QTTEK 236_ LYFVL 241_ DFVNG 246_ GELFF 251_ HLQRE 256_ RSFPE 261_ HRARF 266_ YAAEI 271_ ASALG 276_ YLHSI 281_ KIVYR 286_ DLKPE 291_ NILLD 296_ SVGHV 301_ VLTDF 306_ GLCKE 311_ GIAIS 316_ DTTTT 321_ FCGTP 326_ EYLAP 331_ EVIRK 336_ QPYDN 341_ TVDWW 346_ CLGAV 351_ LYEML 356_ YGLPP 361_ FYCRD 366_ VAEMY 371_ DNILH 376_ KPLSL 381_ RPGVS 386_ LTAWS 391_ ILEEL 396_ LEKDR 401_ QNRLG 406_ AKEDF 411_ LEIQN 416_ HPFFE 421_ SLSWA 426_ DLVQK 431_ KIPPP 436_ FNPNV 441_ AGPDD 446_ IRNFD 451_ TAFTE 456_ ETVPY 461_ SVCVS 466_ SDYSI 471_ VNASV 476_ LEADD 481_ AFVGF 486_ SYAPP 491_SEDLF
1: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes