Calcineurin B homologous protein 3 (Tescalcin) (TSC)
1_MGAAH 6_ SASEE 11_ VRELE 16_ GKTGF 21_ SSDQI 26_ EQLHR 31_ RFKQL 36_ SGDQP 41_ TIRKE 46_ NFNNV 51_ PDLEL 56_ NPIRS 61_ KIVRA 66_ FFDNR 71_ NLRKG 76_ PSGLA 81_ DEINF 86_ EDFLT 91_ IMSYF 96_ RPIDT 101_ TMDEE 106_ QVELS 111_ RKEKL 116_ RFLFH 121_ MYDSD 126_ SDGRI 131_ TLEEY 136_ RNVVE 141_ ELLSG 146_ NPHIE 151_ KESAR 156_ SIADG 161_ AMMEA 166_ ASVCM 171_ GQMEP 176_ DQVYE 181_ GITFE 186_ DFLKI 191_ WQGID 196_ IETKM 201_ HVRFL 206_NMETM
1: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin