Centromere protein T (CENP-T) (Interphase centromere complex protein 22)
1_MADHN 6_ PDSDS 11_ TPRTL 16_ LRRVL 21_ DTADP 26_ RTPRR 31_ PRSAR 36_ AGARR 41_ ALLET 46_ ASPRK 51_ LSGQT 56_ RTIAR 61_ GRSHG 66_ ARSVG 71_ RSAHI 76_ QASGH 81_ LEEQT 86_ PRTLL 91_ KNILL 96_ TAPES 101_ SILMP 106_ ESVVK 111_ PVPAP 116_ QAVQP 121_ SRQES 126_ SCGSL 131_ ELQLP 136_ ELEPP 141_ TTLAP 146_ GLLAP 151_ GRRKQ 156_ RLRLS 161_ VFQQG 166_ VDQGL 171_ SLSQE 176_ PQGNA 181_ DASSL 186_ TRSLN 191_ LTFAT 196_ PLQPQ 201_ SVQRP 206_ GLARR 211_ PPARR 216_ AVDVG 221_ AFLRD 226_ LRDTS 231_ LAPPN 236_ IVLED 241_ TQPFS 246_ QPMVG 251_ SPNVY 256_ HSLPC 261_ TPHTG 266_ AEDAE 271_ QAAGR 276_ KTQSS 281_ GPGLQ 286_ KNSPG 291_ KPAQF 296_ LAGEA 301_ EEVNA 306_ FALGF 311_ LSTSS 316_ GVSGE 321_ DEVEP 326_ LHDGV 331_ EEAEK 336_ KMEEE 341_ GVSVS 346_ EMEAT 351_ GAQGP 356_ SRVEE 361_ AEGHT 366_ EVTEA 371_ EGSQG 376_ TAEAD 381_ GPGAS 386_ SGDED 391_ ASGRA 396_ ASPES 401_ ASSTP 406_ ESLQA 411_ RRHHQ 416_ FLEPA 421_ PAPGA 426_ AVLSS 431_ EPAEP 436_ LLVRH 441_ PPRPR 446_ TTGPR 451_ PRQDP 456_ HKAGL 461_ SHYVK 466_ LFSFY 471_ AKMPM 476_ ERKAL 481_ EMVEK 486_ CLDKY 491_ FQHLC 496_ DDLEV 501_ FAAHA 506_ GRKTV 511_ KPEDL 516_ ELLMR 521_ RQGLV 526_ TDQVS 531_ LHVLV 536_ ERHLP 541_ LEYRQ 546_ LLIPC 551_ AYSGN 556_SVFPA
1: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis