Alkylated DNA repair protein alkB homolog 8 (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229)
1_MDSNH 6_ QSNYK 11_ LSKTE 16_ KKFLR 21_ KQIKA 26_ KHTLL 31_ RHEGI 36_ ETVSY 41_ ATQSL 46_ VVANG 51_ GLGNG 56_ VSRNQ 61_ LLPVL 66_ EKCGL 71_ VDALL 76_ MPPNK 81_ PYSFA 86_ RYRTT 91_ EESKR 96_ AYVTL 101_ NGKEV 106_ VDDLG 111_ QKITL 116_ YLNFV 121_ EKVQW 126_ KELRP 131_ QALPP 136_ GLMVV 141_ EEIIS 146_ SEEEK 151_ MLLES 156_ VDWTE 161_ DTDNQ 166_ NSQKS 171_ LKHRR 176_ VKHFG 181_ YEFHY 186_ ENNNV 191_ DKDKP 196_ LSGGL 201_ PDICE 206_ SFLEK 211_ WLRKG 216_ YIKHK 221_ PDQMT 226_ INQYE 231_ PGQGI 236_ PAHID 241_ THSAF 246_ EDEIV 251_ SLSLG 256_ SEIVM 261_ DFKHP 266_ DGIAV 271_ PVMLP 276_ RRSLL 281_ VMTGE 286_ SRYLW 291_ THGIT 296_ CRKFD 301_ TVQAS 306_ ESLKS 311_ GIITS 316_ DVGDL 321_ TLSKR 326_ GLRTS 331_ FTFRK 336_ VRQTP 341_ CNCSY 346_ PLVCD 351_ SQRKE 356_ TPPSF 361_ PESDK 366_ EASRL 371_ EQEYV 376_ HQVYE 381_ EIAGH 386_ FSSTR 391_ HTPWP 396_ HIVEF 401_ LKALP 406_ SGSIV 411_ ADIGC 416_ GNGKY 421_ LGINK 426_ ELYMI 431_ GCDRS 436_ QNLVD 441_ ICRER 446_ QFQAF 451_ VCDAL 456_ AVPVR 461_ SGSCD 466_ ACISI 471_ AVIHH 476_ FATAE 481_ RRVAA 486_ LQEIV 491_ RLLRP 496_ GGKAL 501_ IYVWA 506_ MEQEY 511_ NKQKS 516_ KYLRG 521_ NRNSQ 526_ GKKEE 531_ MNSDT 536_ SVQRS 541_ LVEQM 546_ RDMGS 551_ RDSAS 556_ SVPRI 561_ NDSQE 566_ GGCNS 571_ RQVSN 576_ SKLPV 581_ HVNRT 586_ SFYSQ 591_ DVLVP 596_ WHLKG 601_ NPDKG 606_ KPVEP 611_ FGPIG 616_ SQDPS 621_ PVFHR 626_ YYHVF 631_ REGEL 636_ EGACR 641_ TVSDV 646_ RILQS 651_ YYDQG 656_NWCVI
1: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182)