Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)
1_MTLRL 6_ LEDWC 11_ RGMDM 16_ NPRKA 21_ LLIAG 26_ ISQSC 31_ SVAEI 36_ EEALQ 41_ AGLAP 46_ LGEYR 51_ LLGRM 56_ FRRDE 61_ NRKVA 66_ LVGLT 71_ AETSH 76_ ALVPK 81_ EIPGK 86_ GGIWR 91_ VIFKP 96_ PDPDN 101_ TFLSR 106_ LNEFL 111_ AGEGM 116_ TVGEL 121_ SRALG 126_ HENGS 131_ LDPEQ 136_ GMIPE 141_ MWAPM 146_ LAQAL 151_ EALQP 156_ ALQCL 161_ KYKKL 166_ RVFSG 171_ RESPE 176_ PGEEE 181_ FGRWM 186_ FHTTQ 191_ MIKAW 196_ QVPDV 201_ EKRRR 206_ LLESL 211_ RGPAL 216_ DVIRV 221_ LKINN 226_ PLITV 231_ DECLQ 236_ ALEEV 241_ FGVTD 246_ NPREL 251_ QVKYL 256_ TTYQK 261_ DEEKL 266_ SAYVL 271_ RLEPL 276_ LQKLV 281_ QRGAI 286_ ERDAV 291_ NQARL 296_ DQVIA 301_ GAVHK 306_ TIRRE 311_ LNLPE 316_ DGPAP 321_ GFLQL 326_ LVLIK 331_ DYEAA 336_ EEEEA 341_ LLQAI 346_LEGNF
1: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215)