Autophagy-related protein 2 homolog B
1_MPWPF 6_ SESIK 11_ KRACR 16_ YLLQR 21_ YLGHF 26_ LQEKL 31_ SLEQL 36_ SLDLY 41_ QGTGS 46_ LAQVP 51_ LDKWC 56_ LNEIL 61_ ESADA 66_ PLEVT 71_ EGFIQ 76_ SISLS 81_ VPWGS 86_ LLQDN 91_ CALEV 96_ RGLEM 101_ VFRPR 106_ PRPAT 111_ GSEPM 116_ YWSSF 121_ MTSSM 126_ QLAKE 131_ CLSQK 136_ LTDEQ 141_ GEGSQ 146_ PFEGL 151_ EKFAE 156_ TIETV 161_ LRRVK 166_ VTFID 171_ TVLRI 176_ EHVPE 181_ NSKTG 186_ TALEI 191_ RIERT 196_ VYCDE 201_ TADES 206_ SGINV 211_ HQPTA 216_ FAHKL 221_ LQLSG 226_ VSLFW 231_ DEFSA 236_ SAKSS 241_ PVCST 246_ APVET 251_ EPKLS 256_ PSWNP 261_ KIIYE 266_ PHPQL 271_ TRNLP 276_ EIAPS 281_ DPVQI 286_ GRLIG 291_ RLELS 296_ LTLKQ 301_ NEVLP 306_ GAKLD 311_ VDGQI 316_ DSIHL 321_ LLSPR 326_ QVHLL 331_ LDMLA 336_ AIAGP 341_ ENSSK 346_ IGLAN 351_ KDRKN 356_ RPMQQ 361_ EDEYR 366_ IQMEL 371_ NRYYL 376_ RKDSL 381_ SVGVS 386_ SEQSF 391_ YETET 396_ ARTPS 401_ SREEE 406_ VFFSM 411_ ADMDM 416_ SHSLS 421_ SLPPL 426_ GDPPN 431_ MDLEL 436_ SLTST 441_ YTNTP 446_ AGSPL 451_ SATVL 456_ QPTWG 461_ EFLDH 466_ HKEQP 471_ VRGST 476_ FPSNL 481_ VHPTP 486_ LQKTS 491_ LPSRS 496_ VSVDE 501_ SRPEL 506_ IFRLA 511_ VGTFS 516_ ISVLH 521_ IDPLS 526_ PPETS 531_ QNLNP 536_ LTPMA 541_ VAFFT 546_ CIEKI 551_ DPARF 556_ STEDF 561_ KSFRA 566_ VFAEA 571_ CSHDH 576_ LRFIG 581_ TGIKV 586_ SYEQR 591_ QRSAS 596_ RYFST 601_ DMSIG 606_ QMEFL 611_ ECLFP 616_ TDFHS 621_ VPPHY 626_ TELLT 631_ FHSKE 636_ ETGSH 641_ SPVCL 646_ QLHYK 651_ HSENR 656_ GPQGN 661_ QARLS 666_ SVPHK 671_ AELQI 676_ KLNPV 681_ CCELD 686_ ISIVD 691_ RLNSL 696_ LQPQK 701_ LATVE 706_ MMASH 711_ MYTSY 716_ NKHIS 721_ LHKAF 726_ TEVFL 731_ DDSHS 736_ PANCR 741_ ISVQV 746_ ATPAL 751_ NLSVR 756_ FPIPD 761_ LRSDQ 766_ ERGPW 771_ FKKSL 776_ QKEIL 781_ YLAFT 786_ DLEFK 791_ TEFIG 796_ GSTPE 801_ QIKLE 806_ LTFRE 811_ LIGSF 816_ QEEKG 821_ DPSIK 826_ FFHVS 831_ SGVDG 836_ DTTSS 841_ DDFDW 846_ PRIVL 851_ KINPP 856_ AMHSI 861_ LERIA 866_ AEEEE 871_ ENDGH 876_ YQEEE 881_ EGGAH 886_ SLKDV 891_ CDLRR 896_ PAPSP 901_ FSSRR 906_ VMFEN 911_ EQMVM 916_ PGDPV 921_ EMTEF 926_ QDKAI 931_ SNSHY 936_ VLELT 941_ LPNIY 946_ VTLPN 951_ KSFYE 956_ KLYNR 961_ IFNDL 966_ LLWEP 971_ TAPSP 976_ VETFE 981_ NISYG 986_ IGLSV 991_ ASQLI 996_ NTFNK 1001_ DSFSA 1006_ FKSAV 1011_ HYDEE 1016_ SGSEE 1021_ ETLQY 1026_ FSTVD 1031_ PNYRS 1036_ RRKKK 1041_ LDSQN 1046_ KNSQS 1051_ FLSVL 1056_ LNINH 1061_ GLIAV 1066_ FTDVK 1071_ QDNGD 1076_ LLENK 1081_ HGEFW 1086_ LEFNS 1091_ GSLFC 1096_ VTKYE 1101_ GFDDK 1106_ HYICL 1111_ HSSSF 1116_ SLYHK 1121_ GIVNG 1126_ VILPT 1131_ ETRLP 1136_ SSTRP 1141_ HWLEP 1146_ TIYSS 1151_ EEDGL 1156_ SKTSS 1161_ DGVGG 1166_ DSLNM 1171_ LSVAV 1176_ KILSD 1181_ KSESN 1186_ TKEFL 1191_ IAVGL 1196_ KGATL 1201_ QHRML 1206_ PSGLS 1211_ WHEQI 1216_ LYFLN 1221_ IADEP 1226_ VLGYN 1231_ PPTSF 1236_ TTFHV 1241_ HLWSC 1246_ ALDYR 1251_ PLYLP 1256_ IRSLL 1261_ TVETF 1266_ SVSSS 1271_ VALDK 1276_ SSSTL 1281_ RIILD 1286_ EAALH 1291_ LSDKC 1296_ NTVTI 1301_ NLSRD 1306_ YVRVM 1311_ DMGLL 1316_ ELTIT 1321_ AVKSD 1326_ SDGEQ 1331_ TEPRF 1336_ ELHCS 1341_ SDVVH 1346_ IRTCS 1351_ DSCAA 1356_ LMNLI 1361_ QYIAS 1366_ YGDLQ 1371_ TPNKA 1376_ DMKPG 1381_ AFQRR 1386_ SKVDS 1391_ SGRSS 1396_ SRGPV 1401_ LPEAD 1406_ QQMLR 1411_ DLMSD 1416_ AMEEI 1421_ DMQQG 1426_ TSSVK 1431_ PQANG 1436_ VLDEK 1441_ SQIQE 1446_ PCCSD 1451_ LFLFP 1456_ DESGN 1461_ VSQES 1466_ GPTYA 1471_ SFSHH 1476_ FISDA 1481_ MTGVP 1486_ TENDD 1491_ FCILF 1496_ APKAA 1501_ MQEKE 1506_ EEPVI 1511_ KIMVD 1516_ DAIVI 1521_ RDNYF 1526_ SLPVN 1531_ KTDTS 1536_ KAPLH 1541_ FPIPV 1546_ IRYVV 1551_ KEVSL 1556_ VWHLY 1561_ GGKDF 1566_ GIVPP 1571_ TSPAK 1576_ SYISP 1581_ HSSPS 1586_ HTPTR 1591_ HGRNT 1596_ VCGGK 1601_ GRNHD 1606_ FLMEI 1611_ QLSKV 1616_ KFQHE 1621_ VYPPC 1626_ KPDCD 1631_ SSLSE 1636_ HPVSR 1641_ QVFIV 1646_ QDLEI 1651_ RDRLA 1656_ TSQMN 1661_ KFLYL 1666_ YCSKE 1671_ MPRKA 1676_ HSNML 1681_ TVKAL 1686_ HVCPE 1691_ SGRSP 1696_ QECCL 1701_ RVSLM 1706_ PLRLN 1711_ IDQDA 1716_ LFFLK 1721_ DFFTS 1726_ LSAEV 1731_ ELQMT 1736_ PDPEV 1741_ KKSPG 1746_ ADVTC 1751_ SLPRH 1756_ LSTSK 1761_ EPNLV 1766_ ISFSG 1771_ PKQPS 1776_ QNDSA 1781_ NSVEV 1786_ VNGME 1791_ EKNFS 1796_ AEEAS 1801_ FRDQP 1806_ VFFRE 1811_ FRFTS 1816_ EVPIR 1821_ LDYHG 1826_ KHVSM 1831_ DQGTL 1836_ AGILI 1841_ GLAQL 1846_ NCSEL 1851_ KLKRL 1856_ SYRHG 1861_ LLGVD 1866_ KLFSY 1871_ AITEW 1876_ LNDIK 1881_ KNQLP 1886_ GILGG 1891_ VGPMH 1896_ SLVQL 1901_ VQGLK 1906_ DLVWL 1911_ PIEQY 1916_ RKDGR 1921_ IVRGF 1926_ QRGAA 1931_ SFGTS 1936_ TAMAA 1941_ LELTN 1946_ RMVQT 1951_ IQAAA 1956_ ETAYD 1961_ MVSPG 1966_ TLSIE 1971_ PKKTK 1976_ RFPHH 1981_ RLAHQ 1986_ PVDLR 1991_ EGVAK 1996_ AYSVV 2001_ KEGIT 2006_ DTAQT 2011_ IYETA 2016_ AREHE 2021_ SRGVT 2026_ GAVGE 2031_ VLRQI 2036_ PPAVV 2041_ KPLIV 2046_ ATEAT 2051_ SNVLG 2056_ GMRNQ 2061_ IRPDV 2066_ RQDES 2071_QKWRH
1: Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365)