Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66)
1_MAAAC 6_ GPGAA 11_ GYCLL 16_ LGLHL 21_ FLLTA 26_ GPALG 31_ WNDPD 36_ RMLLR 41_ DVKAL 46_ TLHYD 51_ RYTTS 56_ RRLDP 61_ IPQLK 66_ CVGGT 71_ AGCDS 76_ YTPKV 81_ IQCQN 86_ KGWDG 91_ YDVQW 96_ ECKTD 101_ LDIAY 106_ KFGKT 111_ VVSCE 116_ GYESS 121_ EDQYV 126_ LRGSC 131_ GLEYN 136_ LDYTE 141_ LGLQK 146_ LKESG 151_ KQHGF 156_ ASFSD 161_ YYYKW 166_ SSADS 171_ CNMSG 176_ LITIV 181_ VLLGI 186_ AFVVY 191_ KLFLS 196_ DGQYS 201_ PPPYS 206_ EYPPF 211_ SHRYQ 216_ RFTNS 221_ AGPPP 226_ PGFKS 231_ EFTGP 236_ QNTGH 241_ GATSG 246_ FGSAF 251_ TGQQG 256_ YENSG 261_ PGFWT 266_ GLGTG 271_ GILGY 276_ LFGSN 281_ RAATP 286_ FSDSW 291_ YYPSY 296_ PPSYP 301_ GTWNR 306_ AYSPL 311_ HGGSG 316_ SYSVC 321_ SNSDT 326_ KTRTA 331_SGYGG
1: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions