TBC1 domain family member 20
1_MALRS 6_ AQGDG 11_ PTSGH 16_ WDGGA 21_ EKADF 26_ NAKRK 31_ KKVAE 36_ IHQAL 41_ NSDPT 46_ DVAAL 51_ RRMAI 56_ SEGGL 61_ LTDEI 66_ RRKVW 71_ PKLLN 76_ VNAND 81_ PPPIS 86_ GKNLR 91_ QMSKD 96_ YQQVL 101_ LDVRR 106_ SLRRF 111_ PPGMP 116_ EEQRE 121_ GLQEE 126_ LIDII 131_ LLILE 136_ RNPQL 141_ HYYQG 146_ YHDIV 151_ VTFLL 156_ VVGER 161_ LATSL 166_ VEKLS 171_ THHLR 176_ DFMDP 181_ TMDNT 186_ KHILN 191_ YLMPI 196_ IDQVN 201_ PELHD 206_ FMQSA 211_ EVGTI 216_ FALSW 221_ LITWF 226_ GHVLS 231_ DFRHV 236_ VRLYD 241_ FFLAC 246_ HPLMP 251_ IYFAA 256_ VIVLY 261_ REQEV 266_ LDCDC 271_ DMASV 276_ HHLLS 281_ QIPQD 286_ LPYET 291_ LISRA 296_ GDLFV 301_ QFPPS 306_ ELARE 311_ AAAQQ 316_ QAERT 321_ AASTF 326_ KDFEL 331_ ASAQQ 336_ RPDMV 341_ LRQRF 346_ RGLLR 351_ PEDRT 356_ KDVLT 361_ KPRTN 366_ RFVKL 371_ AVMGL 376_ TVALG 381_ AAALA 386_ VVKSA 391_ LEWAP 396_KFQLQ
1: GTPase-activating protein (GAP) specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (PubMed:23236136). Also shows GAP activity for RAB18 GTPase (PubMed:26063829). Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis (PubMed:26063829). Involved in maintaining endoplasmic reticulum structure (PubMed:24891604)