Armadillo repeat-containing protein 5
1_MAAAK 6_ PTLTD 11_ SLSFC 16_ LAQLA 21_ AAAGE 26_ ALGGE 31_ KDPAT 36_ NETPL 41_ SRALL 46_ ALRTR 51_ HIKAA 56_ GGIER 61_ FRARG 66_ GLRPL 71_ LALLR 76_ RAAAA 81_ GSAPS 86_ QAGPG 91_ SAPSS 96_ AASGA 101_ SSPAP 106_ ASGPA 111_ PSAVS 116_ SSSPT 121_ PPVRL 126_ RKTLD 131_ LALSI 136_ LADCC 141_ TEGAC 146_ RTEVR 151_ RLGGI 156_ LPLVT 161_ ILQCM 166_ KTDSI 171_ QNRTA 176_ RALGN 181_ LAMEP 186_ ESCGD 191_ IHCAG 196_ AVPLL 201_ VESLT 206_ ACQDS 211_ QCLQS 216_ VVRAL 221_ RNLAD 226_ SPQHR 231_ LALAQ 236_ QGAVR 241_ PLAEL 246_ LATAP 251_ DAALT 256_ LALVR 261_ ALLEL 266_ SRGCS 271_ RACAE 276_ QLSLG 281_ GGLGP 286_ LVSLA 291_ SHPKR 296_ AVREG 301_ TILIL 306_ ANLCA 311_ QGLIR 316_ PALGN 321_ AGGVE 326_ VLVDE 331_ LRQRR 336_ DPNGA 341_ SPTSQ 346_ QPLVR 351_ AVCLL 356_ CREAI 361_ NRARL 366_ RDAGG 371_ LDLLM 376_ GLLRD 381_ PRASA 386_ WHPRI 391_ VAALV 396_ GFLYD 401_ TGALG 406_ RLQAL 411_ GLVPL 416_ LAGQL 421_ CGEAG 426_ EEEEE 431_ GREAA 436_ SWDFP 441_ EERTP 446_ ERAQG 451_ GSFRS 456_ LRSWL 461_ ISEGY 466_ ATGPD 471_ DISPD 476_ WSPEQ 481_ CPPEP 486_ MEPAS 491_ PAPTP 496_ TSLRA 501_ PRTQR 506_ TPGRS 511_ PAAAI 516_ EEPWG 521_ REGPA 526_ LLLLS 531_ RFSQA 536_ PDPSG 541_ ALVTG 546_ PALYG 551_ LLTYV 556_ TGAPG 561_ PPSPR 566_ ALRIL 571_ SRLTC 576_ NPACL 581_ EAFVR 586_ SYGAA 591_ LLRAW 596_ LVLGV 601_ APDDW 606_ PAPRA 611_ RPTLH 616_ SRHRE 621_ LGERL 626_ LQNLT 631_ VQAES 636_ PFGVG 641_ ALTHL 646_ LLSGS 651_ PEDRV 656_ ACALT 661_ LPFIC 666_ RKPSL 671_ WRRLL 676_ LEQGG 681_ LRLLL 686_ AALTR 691_ PAPHP 696_ LFLFF 701_ AADSL 706_ SCLQD 711_ LVSPT 716_ VSPAV 721_ PQAVP 726_ MDLDS 731_ PSPCL 736_ YEPLL 741_ GPAPV 746_ PAPDL 751_ HFLLD 756_ SGLQL 761_ PAQRA 766_ ASATA 771_ SPFFR 776_ ALLSG 781_ SFAEA 786_ QMDLV 791_ PLRGL 796_ SPGAA 801_ WPVLH 806_ HLHGC 811_ RGCGA 816_ ALGPV 821_ PPPGQ 826_ PLLGS 831_ EAEEA 836_ LEAAG 841_ RFLLP 846_ GLEEE 851_ LEEAV 856_ GRIHL 861_ GPQGG 866_ PESVG 871_ EVFRL 876_ GRPRL 881_ AAHCA 886_ RWTLG 891_ SEQCP 896_ RKRGL 901_ ALVGL 906_ VEAAG 911_ EEAGP 916_ LTEAL 921_ LAVVM 926_GIELG
1: Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429)