Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)
1_MASVT 6_ RAVFG 11_ ELPSG 16_ GGTVE 21_ KFQLQ 26_ SDLLR 31_ VDIIS 36_ WGCTI 41_ TALEV 46_ KDRQG 51_ RASDV 56_ VLGFA 61_ ELEGY 66_ LQKQP 71_ YFGAV 76_ IGRVA 81_ NRIAK 86_ GTFKV 91_ DGKEY 96_ HLAIN 101_ KEPNS 106_ LHGGV 111_ RGFDK 116_ VLWTP 121_ RVLSN 126_ GVQFS 131_ RISPD 136_ GEEGY 141_ PGELK 146_ VWVTY 151_ TLDGG 156_ ELIVN 161_ YRAQA 166_ SQATP 171_ VNLTN 176_ HSYFN 181_ LAGQA 186_ SPNIN 191_ DHEVT 196_ IEADT 201_ YLPVD 206_ ETLIP 211_ TGEVA 216_ PVQGT 221_ AFDLR 226_ KPVEL 231_ GKHLQ 236_ DFHLN 241_ GFDHN 246_ FCLKG 251_ SKEKH 256_ FCARV 261_ HHAAS 266_ GRVLE 271_ VYTTQ 276_ PGVQF 281_ YTGNF 286_ LDGTL 291_ KGKNG 296_ AVYPK 301_ HSGFC 306_ LETQN 311_ WPDAV 316_ NQPRF 321_ PPVLL 326_ RPGEE 331_ YDHTT 336_WFKFS
1: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898). Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898)