Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)
1_MSVGF 6_ IGAGQ 11_ LAYAL 16_ ARGFT 21_ AAGIL 26_ SAHKI 31_ IASSP 36_ EMNLP 41_ TVSAL 46_ RKMGV 51_ NLTRS 56_ NKETV 61_ KHSDV 66_ LFLAV 71_ KPHII 76_ PFILD 81_ EIGAD 86_ VQARH 91_ IVVSC 96_ AAGVT 101_ ISSVE 106_ KKLMA 111_ FQPAP 116_ KVIRC 121_ MTNTP 126_ VVVQE 131_ GATVY 136_ ATGTH 141_ ALVED 146_ GQLLE 151_ QLMSS 156_ VGFCT 161_ EVEED 166_ LIDAV 171_ TGLSG 176_ SGPAY 181_ AFMAL 186_ DALAD 191_ GGVKM 196_ GLPRR 201_ LAIQL 206_ GAQAL 211_ LGAAK 216_ MLLDS 221_ EQHPC 226_ QLKDN 231_ VCSPG 236_ GATIH 241_ ALHFL 246_ ESGGF 251_ RSLLI 256_ NAVEA 261_ SCIRT 266_ RELQS 271_ MADQE 276_ KISPA 281_ ALKKT 286_ LLDRV 291_ KLESP 296_ TVSTL 301_ TPSSP 306_ GKLLT 311_RSLAL
1: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:23024808, PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+) (PubMed:2722838, PubMed:6894153)