m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)
1_MADAA 6_ PQLGK 11_ RKREL 16_ DVEEA 21_ HAAST 26_ EEKEA 31_ GVGNG 36_ TCAPV 41_ RLPFS 46_ GFRLQ 51_ KVLRE 56_ SARDK 61_ IIFLH 66_ GKVNE 71_ ASGDG 76_ DGEDA 81_ VVILE 86_ KTPFQ 91_ VEQVA 96_ QLLTG 101_ SPELQ 106_ LQFSN 111_ DIYST 116_ YHLFP 121_ PRQLN 126_ DVKTT 131_ VVYPA 136_ TEKHL 141_ QKYLR 146_ QDLRL 151_ IRETG 156_ DDYRN 161_ ITLPH 166_ LESQS 171_ LSIQW 176_ VYNIL 181_ DKKAE 186_ ADRIV 191_ FENPD 196_ PSDGF 201_ VLIPD 206_ LKWNQ 211_ QQLDD 216_ LYLIA 221_ ICHRR 226_ GIRSL 231_ RDLTP 236_ EHLPL 241_ LRNIL 246_ HQGQE 251_ AILQR 256_ YRMKG 261_ DHLRV 266_ YLHYL 271_ PSYYH 276_ LHVHF 281_ TALGF 286_ EAPGS 291_ GVERA 296_ HLLAE 301_ VIENL 306_ ECDPR 311_ HYQQR 316_ TLTFA 321_ LRADD 326_ PLLKL 331_LQEAQ
1: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death