Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3)
1_MSGYQ 6_ RRPGA 11_ TPLSR 16_ ARSLA 21_ IPDAP 26_ AFYER 31_ RSCLP 36_ QLNCE 41_ RPHGR 46_ DLDSP 51_ FFGIR 56_ PAFMC 61_ YVPSP 66_ VLASV 71_ GDTDF 76_ GYGKG 81_ KCSKQ 86_ SPSGA 91_ HGTHF 96_ GDDRF 101_ EDLEE 106_ ANPFS 111_ FREFL 116_ KTKNL 121_ GLSKE 126_ DPASR 131_ IYAKE 136_ ASRHS 141_ LGLDH 146_ NSPPS 151_ QTGGY 156_ GLEYQ 161_ QPFFE 166_ DPTGA 171_ GDLLD 176_ EEEDE 181_ DTGWS 186_ GAYLP 191_ SAIEQ 196_ THPER 201_ VPAGT 206_ SPCST 211_ YLSFF 216_ STPSE 221_ LAGPE 226_ SLPSW 231_ ALSDT 236_ DSRVS 241_ PASPA 246_ GSPSA 251_ DFAVH 256_ GESLG 261_ DRHLR 266_ TLQIS 271_ YDALK 276_ DENSK 281_ LRRKL 286_ NEVQS 291_ FSEAQ 296_ TEMVR 301_ TLERK 306_ LEAKM 311_ IKEES 316_ DYHDL 321_ ESVVQ 326_ QVEQN 331_ LELMT 336_ KRAVK 341_ AENHV 346_ VKLKQ 351_ EISLL 356_ QAQVS 361_ NFQRE 366_ NEALR 371_ CGQGA 376_ SLTVV 381_ KQNAD 386_ VALQN 391_ LRVVM 396_ NSAQA 401_ SIKQL 406_ VSGAE 411_ TLNLV 416_ AEILK 421_ SIDRI 426_SEVKD
1: Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity)