Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
1_MGPKD 6_ SAKCL 11_ HRGPQ 16_ PSHWA 21_ AGDGP 26_ TQERC 31_ GPRSL 36_ GSPVL 41_ GLDTC 46_ RAWDH 51_ VDGQI 56_ LGQLR 61_ PLTEE 66_ EEEEG 71_ AGATL 76_ SRGPA 81_ FPGMG 86_ SEELR 91_ LASFY 96_ DWPLT 101_ AEVPP 106_ ELLAA 111_ AGFFH 116_ TGHQD 121_ KVRCF 126_ FCYGG 131_ LQSWK 136_ RGDDP 141_ WTEHA 146_ KWFPS 151_ CQFLL 156_ RSKGR 161_ DFVHS 166_ VQETH 171_ SQLLG 176_ SWDPW 181_ EEPED 186_ AAPVA 191_ PSVPA 196_ SGYPE 201_ LPTPR 206_ REVQS 211_ ESAQE 216_ PGGVS 221_ PAEAQ 226_ RAWWV 231_ LEPPG 236_ ARDVE 241_ AQLRR 246_ LQEER 251_ TCKVC 256_ LDRAV 261_ SIVFV 266_ PCGHL 271_ VCAEC 276_ APGLQ 281_ LCPIC 286_ RAPVR 291_SRVRT
1: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045)
2: Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418)
3: Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418)