Integrator complex subunit 12 (Int12) (PHD finger protein 22)
1_MAATV 6_ NLELD 11_ PIFLK 16_ ALGFL 21_ HSKSK 26_ DSAEK 31_ LKALL 36_ DESLA 41_ RGIDS 46_ SYRPS 51_ QKDVE 56_ PPKIS 61_ STKNI 66_ SIKQE 71_ PKISS 76_ SLPSG 81_ NNNGK 86_ VLTTE 91_ KVKKE 96_ AEKRP 101_ ADKMK 106_ SDITE 111_ GVDIP 116_ KKPRL 121_ EKPET 126_ QSSPI 131_ TVQSS 136_ KDLPM 141_ ADLSS 146_ FEETS 151_ ADDFA 156_ MEMGL 161_ ACVVC 166_ RQMMV 171_ ASGNQ 176_ LVECQ 181_ ECHNL 186_ YHRDC 191_ HKPQV 196_ TDKEA 201_ NDPRL 206_ VWYCA 211_ RCTRQ 216_ MKRMA 221_ QKTQK 226_ PPQKP 231_ APAVV 236_ SVTPA 241_ VKDPL 246_ VKKPE 251_ TKLKQ 256_ ETTFL 261_ AFKRT 266_ EVKTS 271_ TVISG 276_ NSSSA 281_ SVSSS 286_ VTSGL 291_ TGWAA 296_ FAAKT 301_ SSAGP 306_ STAKL 311_ SSTTQ 316_ NNTGK 321_ PATSS 326_ ANQKP 331_ VGLTG 336_ LATSS 341_ KGGIG 346_ SKIGS 351_ NNSTT 356_ PTVPL 361_ KPPPP 366_ LTLGK 371_ TGLSR 376_ SVSCD 381_ NVSKV 386_ GLPSP 391_ SSLVP 396_ GSSSQ 401_ LSGNG 406_ NSGTS 411_ GPSGS 416_ TTSKT 421_ TSESS 426_ SSPSA 431_ SLKGP 436_ TSQES 441_ QLNAM 446_ KRLQM 451_ VKKKA 456_AQKKL
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)