Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)
1_MSEAR 6_ RDSTS 11_ SLQRK 16_ KPPWL 21_ KLDIP 26_ SAVPL 31_ TAEEP 36_ SFLQP 41_ LRRQA 46_ FLRSV 51_ SMPAE 56_ TAHIS 61_ SPHHE 66_ LRRPV 71_ LQRQT 76_ SITQT 81_ IRRGT 86_ ADWFG 91_ VSKDS 96_ DSTQK 101_ WQRKS 106_ IRHCS 111_ QRYGK 116_ LKPQV 121_ LRELD 126_ LPSQD 131_ NVSLT 136_ STETP 141_ PPLYV 146_ GPCQL 151_ GMQKI 156_ IDPLA 161_ RGRAF 166_ RVADD 171_ TAEGL 176_ SAPHT 181_ PVTPG 186_ AASLC 191_ SFSSS 196_ RSGFH 201_ RLPRR 206_ RKRES 211_ VAKMS 216_ FRAAA 221_ ALMKG 226_ RSVRD 231_ GTFRR 236_ AQRRS 241_ FTPAS 246_ FLEED 251_ TTDFP 256_ DELDT 261_ SFFAR 266_ EGILH 271_ EELST 276_ YPDEV 281_ FESPS 286_ EAALK 291_ DWEKA 296_ PEQAD 301_ LTGGA 306_ LDRSE 311_ LERSH 316_ LMLPL 321_ ERGWR 326_ KQKEG 331_ AAAPQ 336_ PKVRL 341_ RQEVV 346_ STAGP 351_ RRGQR 356_ IAVPV 361_ RKLFA 366_ REKRP 371_ YGLGM 376_ VGRLT 381_ NRTYR 386_ KRIDS 391_ FVKRQ 396_ IEDMD 401_ DHRPF 406_ FTYWL 411_ TFVHS 416_ LVTIL 421_ AVCIY 426_ GIAPV 431_ GFSQH 436_ ETVDS 441_ VLRNR 446_ GVYEN 451_ VKYVQ 456_ QENFW 461_ IGPSS 466_ EALIH 471_ LGAKF 476_ SPCMR 481_ QDPQV 486_ HSFIR 491_ SARER 496_ EKHSA 501_ CCVRN 506_ DRSGC 511_ VQTSE 516_ EECSS 521_ TLAVW 526_ VKWPI 531_ HPSAP 536_ ELAGH 541_ KRQFG 546_ SVCHQ 551_ DPRVC 556_ DEPSS 561_ EDPHE 566_ WPEDI 571_ TKWPI 576_ CTKNS 581_ AGNHT 586_ NHPHM 591_ DCVIT 596_ GRPCC 601_ IGTKG 606_ RCEIT 611_ SREYC 616_ DFMRG 621_ YFHEE 626_ ATLCS 631_ QVHCM 636_ DDVCG 641_ LLPFL 646_ NPEVP 651_ DQFYR 656_ LWLSL 661_ FLHAG 666_ ILHCL 671_ VSICF 676_ QMTVL 681_ RDLEK 686_ LAGWH 691_ RIAII 696_ YLLSG 701_ VTGNL 706_ ASAIF 711_ LPYRA 716_ EVGPA 721_ GSQFG 726_ ILACL 731_ FVELF 736_ QSWQI 741_ LARPW 746_ RAFFK 751_ LLAVV 756_ LFLFT 761_ FGLLP 766_ WIDNF 771_ AHISG 776_ FISGL 781_ FLSFA 786_ FLPYI 791_ SFGKF 796_ DLYRK 801_ RCQII 806_ IFQVV 811_ FLGLL 816_ AGLVV 821_ LFYVY 826_ PVRCE 831_ WCEFL 836_ TCIPF 841_ TDKFC 846_EKYEL
1: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own