Probable G-protein coupled receptor 146 (G-protein coupled receptor PGR8)
1_MWSCS 6_ WFNGT 11_ GLVEE 16_ LPACQ 21_ DLQLG 26_ LSLLS 31_ LLGLV 36_ VGVPV 41_ GLCYN 46_ ALLVL 51_ ANLHS 56_ KASMT 61_ MPDVY 66_ FVNMA 71_ VAGLV 76_ LSALA 81_ PVHLL 86_ GPPSS 91_ RWALW 96_ SVGGE 101_ VHVAL 106_ QIPFN 111_ VSSLV 116_ AMYST 121_ ALLSL 126_ DHYIE 131_ RALPR 136_ TYMAS 141_ VYNTR 146_ HVCGF 151_ VWGGA 156_ LLTSF 161_ SSLLF 166_ YICSH 171_ VSTRA 176_ LECAK 181_ MQNAE 186_ AADAT 191_ LVFIG 196_ YVVPA 201_ LATLY 206_ ALVLL 211_ SRVRR 216_ EDTPL 221_ DRDTG 226_ RLEPS 231_ AHRLL 236_ VATVC 241_ TQFGL 246_ WTPHY 251_ LILLG 256_ HTVII 261_ SRGKP 266_ VDAHY 271_ LGLLH 276_ FVKDF 281_ SKLLA 286_ FSSSF 291_ VTPLL 296_ YRYMN 301_ QSFPS 306_ KLQRL 311_ MKKLP 316_ CGDRH 321_ CSPDH 326_MGVQQ
1: G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280)