Protein Aster-A (GRAM domain-containing protein 1A)
1_MFDTT 6_ PHSGR 11_ STPSS 16_ SPSLR 21_ KRLQL 26_ LPPSR 31_ PPPEP 36_ EPGTM 41_ VEKGS 46_ DSSSE 51_ KGGVP 56_ GTPST 61_ QSLGS 66_ RNFIR 71_ NSKKM 76_ QSWYS 81_ MLSPT 86_ YKQRN 91_ EDFRK 96_ LFSKL 101_ PEAER 106_ LIVDY 111_ SCALQ 116_ REILL 121_ QGRLY 126_ LSENW 131_ ICFYS 136_ NIFRW 141_ ETTIS 146_ IQLKE 151_ VTCLK 156_ KEKTA 161_ KLIPN 166_ AIQIC 171_ TESEK 176_ HFFTS 181_ FGARD 186_ RCFLL 191_ IFRLW 196_ QNALL 201_ EKTLS 206_ PRELW 211_ HLVHQ 216_ CYGSE 221_ LGLTS 226_ EDEDY 231_ VSPLQ 236_ LNGLG 241_ TPKEV 246_ GDVIA 251_ LSDIT 256_ SSGAA 261_ DRSQE 266_ PSPVG 271_ SRRGH 276_ VTPNL 281_ SRASS 286_ DADHG 291_ AEEDK 296_ EEQVD 301_ SQPDA 306_ SSSQT 311_ VTPVA 316_ EPPST 321_ EPTQP 326_ DGPTT 331_ LGPLD 336_ LLPSE 341_ ELLTD 346_ TSNSS 351_ SSTGE 356_ EADLA 361_ ALLPD 366_ LSGRL 371_ LINSV 376_ FHVGA 381_ ERLQQ 386_ MLFSD 391_ SPFLQ 396_ GFLQQ 401_ CKFTD 406_ VTLSP 411_ WSGDS 416_ KCHQR 421_ RVLTY 426_ TIPIS 431_ NPLGP 436_ KSASV 441_ VETQT 446_ LFRRG 451_ PQAGG 456_ CVVDS 461_ EVLTQ 466_ GIPYQ 471_ DYFYT 476_ AHRYC 481_ ILGLA 486_ RNKAR 491_ LRVSS 496_ EIRYR 501_ KQPWS 506_ LVKSL 511_ IEKNS 516_ WSGIE 521_ DYFHH 526_ LEREL 531_ AKAEK 536_ LSLEE 541_ GGKDA 546_ RGLLS 551_ GLRRR 556_ KRPLS 561_ WRAHG 566_ DGPQH 571_ PDPDP 576_ CARAG 581_ IHTSG 586_ SLSSR 591_ FSEPS 596_ VDQGP 601_ GAGIP 606_ SALVL 611_ ISIVI 616_ CVSLI 621_ ILIAL 626_ NVLLF 631_ YRLWS 636_ LERTA 641_ HTFES 646_ WHSLA 651_ LAKGK 656_ FPQTA 661_ TEWAE 666_ ILALQ 671_ KQFHS 676_ VEVHK 681_ WRQIL 686_ RASVE 691_ LLDEM 696_ KFSLE 701_ KLHQG 706_ ITVSD 711_ PPFDT 716_QPRPD
1: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192)