Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
1_MSHQP 6_ LSCLT 11_ EKEDS 16_ PSEST 21_ GNGPP 26_ HLAHP 31_ NLDTF 36_ TPEEL 41_ LQQMK 46_ ELLTE 51_ NHQLK 56_ EAMKL 61_ NNQAM 66_ KGRFE 71_ ELSAW 76_ TEKQK 81_ EERQF 86_ FEIQS 91_ KEAKE 96_ RLMAL 101_ SHENE 106_ KLKEE 111_ LGKLK 116_ GKSER 121_ SSEDP 126_ TDDSR 131_ LPRAE 136_ AEQEK 141_ DQLRT 146_ QVVRL 151_ QAEKA 156_ DLLGI 161_ VSELQ 166_ LKLNS 171_ SGSSE 176_ DSFVE 181_ IRMAE 186_ GEAEG 191_ SVKEI 196_ KHSPG 201_ PTRTV 206_ STGTA 211_ LSKYR 216_ SRSAD 221_ GAKNY 226_ FEHEE 231_ LTVSQ 236_ LLLCL 241_ REGNQ 246_ KVERL 251_ EVALK 256_ EAKER 261_ VSDFE 266_ KKTSN 271_ RSEIE 276_ TQTEG 281_ STEKE 286_ NDEEK 291_ GPETV 296_ GSEVE 301_ ALNLQ 306_ VTSLF 311_ KELQE 316_ AHTKL 321_ SEAEL 326_ MKKRL 331_ QEKCQ 336_ ALERK 341_ NSAIP 346_ SELNE 351_ KQELV 356_ YTNKK 361_ LELQV 366_ ESMLS 371_ EIKME 376_ QAKTE 381_ DEKSK 386_ LTVLQ 391_ MTHNK 396_ LLQEH 401_ NNALK 406_ TIEEL 411_ TRKES 416_ EKVDR 421_ AVLKE 426_ LSEKL 431_ ELAEK 436_ ALASK 441_ QLQMD 446_ EMKQT 451_ IAKQE 456_ EDLET 461_ MTILR 466_ AQMEV 471_ YCSDF 476_ HAERA 481_ AREKI 486_ HEEKE 491_ QLALQ 496_ LAVLL 501_ KENDA 506_ FEDGG 511_ RQSLM 516_ EMQSR 521_ HGART 526_ SDSDQ 531_ QAYLV 536_ QRGAE 541_ DRDWR 546_ QQRNI 551_ PIHSC 556_ PKCGE 561_ VLPDI 566_ DTLQI 571_HVMDC
1: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52
2: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559)