Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
1_MMWRP 6_ SVLLL 11_ LLLLR 16_ HGAQG 21_ KPSPD 26_ AGPHG 31_ QGRVH 36_ QAAPL 41_ SDAPH 46_ DDAHG 51_ NFQYD 56_ HEAFL 61_ GREVA 66_ KEFDQ 71_ LTPEE 76_ SQARL 81_ GRIVD 86_ RMDRA 91_ GDGDG 96_ WVSLA 101_ ELRAW 106_ IAHTQ 111_ QRHIR 116_ DSVSA 121_ AWDTY 126_ DTDRD 131_ GRVGW 136_ EELRN 141_ ATYGH 146_ YAPGE 151_ EFHDV 156_ EDAET 161_ YKKML 166_ ARDER 171_ RFRVA 176_ DQDGD 181_ SMATR 186_ EELTA 191_ FLHPE 196_ EFPHM 201_ RDIVI 206_ AETLE 211_ DLDRN 216_ KDGYV 221_ QVEEY 226_ IADLY 231_ SAEPG 236_ EEEPA 241_ WVQTE 246_ RQQFR 251_ DFRDL 256_ NKDGH 261_ LDGSE 266_ VGHWV 271_ LPPAQ 276_ DQPLV 281_ EANHL 286_ LHESD 291_ TDKDG 296_ RLSKA 301_ EILGN 306_ WNMFV 311_ GSQAT 316_ NYGED 321_LTRHH
1: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634)