Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365)
1_MHPQV 6_ VILSL 11_ ILHLA 16_ DSVAG 21_ SVKVG 26_ GEAGP 31_ SVTLP 36_ CHYSG 41_ AVTSM 46_ CWNRG 51_ SCSLF 56_ TCQNG 61_ IVWTN 66_ GTHVT 71_ YRKDT 76_ RYKLL 81_ GDLSR 86_ RDVSL 91_ TIENT 96_ AVSDS 101_ GVYCC 106_ RVEHR 111_ GWFND 116_ MKITV 121_ SLEIV 126_ PPKVT 131_ TTPIV 136_ TTVPT 141_ VTTVR 146_ TSTTV 151_ PTTTT 156_ VPMTT 161_ VPTTT 166_ VPTTM 171_ SIPTT 176_ TTVLT 181_ TMTVS 186_ TTTSV 191_ PTTTS 196_ IPTTT 201_ SVPVT 206_ TTVST 211_ FVPPM 216_ PLPRQ 221_ NHEPV 226_ ATSPS 231_ SPQPA 236_ ETHPT 241_ TLQGA 246_ IRREP 251_ TSSPL 256_ YSYTT 261_ DGNDT 266_ VTESS 271_ DGLWN 276_ NNQTQ 281_ LFLEH 286_ SLLTA 291_ NTTKG 296_ IYAGV 301_ CISVL 306_ VLLAL 311_ LGVII 316_ AKKYF 321_ FKKEV 326_ QQLSV 331_ SFSSL 336_ QIKAL 341_ QNAVE 346_ KEVQA 351_ EDNIY 356_IENSL
1: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468)
2: (Microbial infection) Acts as a receptor for Hepatitis A virus
3: (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564)
4: (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433)
5: (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E
6: (Microbial infection) Plays a positive role in Chikungunya virus cell entry