Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B)
1_MWLKV 6_ GGLLR 11_ GTGGQ 16_ LGQTV 21_ GWPCG 26_ ALGPG 31_ PHRWG 36_ PCGGS 41_ WAQKF 46_ YQDGP 51_ GRGLG 56_ EEDIR 61_ RAREA 66_ RPRKT 71_ PRPQL 76_ SDRSR 81_ ERKVP 86_ ASRIS 91_ RLANF 96_ GGLAV 101_ GLGLG 106_ VLAEM 111_ AKKSM 116_ PGGRL 121_ QSEGG 126_ SGLDS 131_ SPFLS 136_ EANAE 141_ RIVQT 146_ LCTVR 151_ GAALK 156_ VGQML 161_ SIQDN 166_ SFISP 171_ QLQHI 176_ FERVR 181_ QSADF 186_ MPRWQ 191_ MLRVL 196_ EEELG 201_ RDWQA 206_ KVASL 211_ EEVPF 216_ AAASI 221_ GQVHQ 226_ GLLRD 231_ GTEVA 236_ VKIQY 241_ PGIAQ 246_ SIQSD 251_ VQNLL 256_ AVLKM 261_ SAALP 266_ AGLFA 271_ EQSLQ 276_ ALQQE 281_ LAWEC 286_ DYRRE 291_ AACAQ 296_ NFRQL 301_ LANDP 306_ FFRVP 311_ AVVKE 316_ LCTTR 321_ VLGME 326_ LAGGV 331_ PLDQC 336_ QGLSQ 341_ DLRNQ 346_ ICFQL 351_ LTLCL 356_ RELFE 361_ FRFMQ 366_ TDPNW 371_ ANFLY 376_ DASSH 381_ QVTLL 386_ DFGAS 391_ REFGT 396_ EFTDH 401_ YIEVV 406_ KAAAD 411_ GDRDC 416_ VLQKS 421_ RDLKF 426_ LTGFE 431_ TKAFS 436_ DAHVE 441_ AVMIL 446_ GEPFA 451_ TQGPY 456_ DFGSG 461_ ETARR 466_ IQDLI 471_ PVLLR 476_ HRLCP 481_ PPEET 486_ YALHR 491_ KLAGA 496_ FLACA 501_ HLRAH 506_ IACRD 511_ LFQDT 516_ YHRYW 521_ ASRQP 526_ DAATA 531_ GSLPT 536_KGDSW
1: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420, PubMed:36302899, PubMed:38425362). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (PubMed:38425362). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (PubMed:38425362). Required for podocyte migration (PubMed:24270420)