Gene name: RNF183

Uniprot entry:

Q96D59

Protein names:

E3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27)

Protein sequence:

1_MAEQQ 6_ GRELE 11_ AECPV 16_ CWNPF 21_ NNTFH 26_ TPKML 31_ DCCHS 36_ FCVEC 41_ LAHLS 46_ LVTPA 51_ RRRLL 56_ CPLCR 61_ QPTVL 66_ ASGQP 71_ VTDLP 76_ TDTAM 81_ LALLR 86_ LEPHH 91_ VILEG 96_ HQLCL 101_ KDQPK 106_ SRYFL 111_ RQPQV 116_ YTLDL 121_ GPQPG 126_ GQTGP 131_ PPDTA 136_ SATVS 141_ TPILI 146_ PSHHS 151_ LRECF 156_ RNPQF 161_ RIFAY 166_ LMAVI 171_ LSVTL 176_ LLIFS 181_ IFWTK 186_QFLWG

Protein annotations

Protein functions:

1: Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849)