Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein)
1_MATWD 6_ EKAVT 11_ RRAKV 16_ APAER 21_ MSKFL 26_ RHFTV 31_ VGDDY 36_ HAWNI 41_ NYKKW 46_ ENEEE 51_ EEEEE 56_ QPPPT 61_ PVSGE 66_ EGRAA 71_ APDVA 76_ PAPGP 81_ APRAP 86_ LDFRG 91_ MLRKL 96_ FSSHR 101_ FQVII 106_ ICLVV 111_ LDALL 116_ VLAEL 121_ ILDLK 126_ IIQPD 131_ KNNYA 136_ AMVFH 141_ YMSIT 146_ ILVFF 151_ MMEII 156_ FKLFV 161_ FRLEF 166_ FHHKF 171_ EILDA 176_ VVVVV 181_ SFILD 186_ IVLLF 191_ QEHQF 196_ EALGL 201_ LILLR 206_ LWRVA 211_ RIING 216_ IIISV 221_ KTRSE 226_ RQLLR 231_ LKQMN 236_ VQLAA 241_ KIQHL 246_ EFSCS 251_ EKEQE 256_ IERLN 261_ KLLRQ 266_HGLLG
1: Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16554753, PubMed:20037153, PubMed:20548053, PubMed:22020278, PubMed:27859356, PubMed:30478045, PubMed:37669933). Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation (PubMed:20144758, PubMed:30478045, PubMed:37669933). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:20037153, PubMed:30478045). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (PubMed:20548053)