Ras-related protein Rab-39B
1_MEAIW 6_ LYQFR 11_ LIVIG 16_ DSTVG 21_ KSCLI 26_ RRFTE 31_ GRFAQ 36_ VSDPT 41_ VGVDF 46_ FSRLV 51_ EIEPG 56_ KRIKL 61_ QIWDT 66_ AGQER 71_ FRSIT 76_ RAYYR 81_ NSVGG 86_ LLLFD 91_ ITNRR 96_ SFQNV 101_ HEWLE 106_ ETKVH 111_ VQPYQ 116_ IVFVL 121_ VGHKC 126_ DLDTQ 131_ RQVTR 136_ HEAEK 141_ LAAAY 146_ GMKYI 151_ ETSAR 156_ DAINV 161_ EKAFT 166_ DLTRD 171_ IYELV 176_ KRGEI 181_ TIQEG 186_ WEGVK 191_ SGFVP 196_ NVVHS 201_ SEEVV 206_KSERR
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). RAB39B is involved in autophagy and may function in autophagosome formation (PubMed:27103069, PubMed:37821429). Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission (By similarity). May regulate the homeostasis of SNCA/alpha-synuclein (By similarity)