Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)
1_MSETS 6_ FNLIS 11_ EKCDI 16_ LSILR 21_ DHPEN 26_ RIYRR 31_ KIEEL 36_ SKRFT 41_ AIRKT 46_ KGDGN 51_ CFYRA 56_ LGYSY 61_ LESLL 66_ GKSRE 71_ IFKFK 76_ ERVLQ 81_ TPNDL 86_ LAAGF 91_ EEHKF 96_ RNFFN 101_ AFYSV 106_ VELVE 111_ KDGSV 116_ SSLLK 121_ VFNDQ 126_ SASDH 131_ IVQFL 136_ RLLTS 141_ AFIRN 146_ RADFF 151_ RHFID 156_ EEMDI 161_ KDFCT 166_ HEVEP 171_ MATEC 176_ DHIQI 181_ TALSQ 186_ ALSIA 191_ LQVEY 196_ VDEMD 201_ TALNH 206_ HVFPE 211_ AATPS 216_ VYLLY 221_ KTSHY 226_NILYA
1: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains