Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16)
1_MAASS 6_ SSSSA 11_ GGVSG 16_ SSVTG 21_ SGFSV 26_ SDLAP 31_ PRKAL 36_ FTYPK 41_ GAGEM 46_ LEDGS 51_ ERFLC 56_ ESVFS 61_ YQVAS 66_ TLKQV 71_ KHDQQ 76_ VARME 81_ KLAGL 86_ VEELE 91_ ADEWR 96_ FKPIE 101_QLLGF
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:20360068). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)