U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)
1_MIEQQ 6_ KRKGP 11_ ELPLV 16_ PVKRQ 21_ RHELL 26_ LGAGS 31_ GPGAG 36_ QQQAT 41_ PGALL 46_ QAGPP 51_ RCSSL 56_ QAPIM 61_ LLSGH 66_ EGEVY 71_ CCKFH 76_ PNGST 81_ LASAG 86_ FDRLI 91_ LLWNV 96_ YGDCD 101_ NYATL 106_ KGHSG 111_ AVMEL 116_ HYNTD 121_ GSMLF 126_ SASTD 131_ KTVAV 136_ WDSET 141_ GERVK 146_ RLKGH 151_ TSFVN 156_ SCYPA 161_ RRGPQ 166_ LVCTG 171_ SDDGT 176_ VKLWD 181_ IRKKA 186_ AIQTF 191_ QNTYQ 196_ VLAVT 201_ FNDTS 206_ DQIIS 211_ GGIDN 216_ DIKVW 221_ DLRQN 226_ KLTYT 231_ MRGHA 236_ DSVTG 241_ LSLSS 246_ EGSYL 251_ LSNAM 256_ DNTVR 261_ VWDVR 266_ PFAPK 271_ ERCVK 276_ IFQGN 281_ VHNFE 286_ KNLLR 291_ CSWSP 296_ DGSKI 301_ AAGSA 306_ DRFVY 311_ VWDTT 316_ SRRIL 321_ YKLPG 326_ HAGSI 331_ NEVAF 336_ HPDEP 341_ IIISA 346_ SSDKR 351_LYMGE
1: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:30315277, PubMed:30705154). Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:16723661, PubMed:26912367, PubMed:9774689). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)