Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)
1_MNGGN 6_ ESSGA 11_ DRAGG 16_ PVATS 21_ VPIGW 26_ QRCVR 31_ EGAVL 36_ YISPS 41_ GTELS 46_ SLEQT 51_ RSYLL 56_ SDGTC 61_ KCGLE 66_ CPLNV 71_ PKVFN 76_ FDPLA 81_ PVTPG 86_ GAGVG 91_ PASEE 96_ DMTKL 101_ CNHRR 106_ KAVAM 111_ ATLYR 116_ SMETT 121_ CSHSS 126_ PGEGA 131_ SPQMF 136_ HTVSP 141_ GPPSA 146_ RPPCR 151_ VPPTT 156_ PLNGG 161_ PGSLP 166_ PEPPS 171_ VSQAF 176_ PTLAG 181_ PGGLF 186_ PPRLA 191_ DPVPS 196_ GGSSS 201_ PRFLP 206_ RGNAP 211_ SPAPP 216_ PPPAI 221_ SLNAP 226_ SYNWG 231_ AALRS 236_ SLVPS 241_ DLGSP 246_ PAPHA 251_ SSSPP 256_ SDPPL 261_ FHCSD 266_ ALTPP 271_ PLPPS 276_ NNLPA 281_ HPGPA 286_ SQPPV 291_ SSATM 296_ HLPLV 301_ LGPLG 306_ GAPTV 311_ EGPGA 316_ PPFLA 321_ SSLLS 326_ AAAKA 331_ QHPPL 336_ PPPST 341_ LQGRR 346_ PRAQA 351_ PSASH 356_ SSSLR 361_ PSQRR 366_ PRRPP 371_ TVFRL 376_ LEGRG 381_ PQTPR 386_ RSRPR 391_ APAPV 396_ PQPFS 401_ LPEPS 406_ QPILP 411_ SVLSL 416_ LGLPT 421_ PGPSH 426_ SDGSF 431_ NLLGS 436_ DAHLP 441_ PPPTL 446_ SSGSP 451_ PQPRH 456_ PIQPS 461_ LPGTT 466_ SGSLS 471_ SVPGA 476_ PAPPA 481_ ASKAP 486_ VVPSP 491_ VLQSP 496_ SEGLG 501_ MGAGP 506_ ACPLP 511_ PLAGG 516_ EAFPF 521_ PSPEQ 526_ GLALS 531_ GAGFP 536_ GMLGA 541_ LPLPL 546_ SLGQP 551_ PPSPL 556_ LNHSL 561_ FGVLT 566_ GGGGQ 571_ PPPEP 576_ LLPPP 581_ GGPGP 586_ PLAPG 591_ EPEGP 596_ SLLVA 601_ SLLPP 606_ PPSDL 611_ LPPPS 616_ APPSN 621_ LLASF 626_ LPLLA 631_ LGPTA 636_ GDGEG 641_ SAEGA 646_ GGPSG 651_ EPFSG 656_ LGDLS 661_ PLLFP 666_ PLSAP 671_ PTLIA 676_ LNSAL 681_ LAATL 686_ DPPSG 691_ TPPQP 696_ CVLSA 701_ PQPGP 706_ PTSSV 711_ TTATT 716_ DPGAS 721_ SLGKA 726_ PSNSG 731_ RPPQL 736_ LSPLL 741_ GASLL 746_ GDLSS 751_ LTSSP 756_ GALPS 761_ LLQPP 766_ GPLLS 771_ GQLGL 776_ QLLPG 781_ GGAPP 786_ PLSEA 791_ SSPLA 796_ CLLQS 801_ LQIPP 806_ EQPEA 811_ PCLPP 816_ ESPAS 821_ ALEPE 826_ PARPP 831_ LSALA 836_ PPHGS 841_ PDPPV 846_ PELLT 851_ GRGSG 856_ KRGRR 861_ GGGGL 866_ RGING 871_ EARPA 876_ RGRKP 881_ GSRRE 886_ PGRLA 891_ LKWGT 896_ RGGFN 901_ GQMER 906_ SPRRT 911_ HHWQH 916_ NGELA 921_ EGGAE 926_ PKDPP 931_ PPGPH 936_ SEDLK 941_ VPPGV 946_ VRKSR 951_ RGRRR 956_ KYNPT 961_ RNSNS 966_ SRQDI 971_ TLEPS 976_ PTARA 981_ AVPLP 986_ PRARP 991_ GRPAK 996_NKRRK
1: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth (PubMed:36180891)