Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)
1_MDGES 6_ EVDFS 11_ SNSIT 16_ PLWRR 21_ RSIPQ 26_ PHQVL 31_ GRSKP 36_ RPQSY 41_ QSPNG 46_ LLITD 51_ FPVED 56_ GGTLL 61_ AAQIP 66_ AQVPT 71_ ASDSR 76_ TVHRS 81_ PLLLG 86_ AQRRA 91_ VANGG 96_ TASPE 101_ YRAAS 106_ PRLRR 111_ PKSPK 116_ LPKAV 121_ PGGSP 126_ KSPAN 131_ GAVTL 136_ PAPPP 141_ PPVLR 146_ PPRTP 151_ NAPAP 156_ CTPEE 161_ DLTGL 166_ TASPV 171_ PSPTA 176_ NGLAA 181_ NNDSP 186_ GSGSQ 191_ SGRKA 196_ KDPER 201_ GLFPG 206_ PQKSS 211_ SEQKL 216_ PLQRL 221_ PSQEN 226_ ELLEN 231_ PSVVL 236_ STNSP 241_ AALKV 246_ GKQQI 251_ IPKSL 256_ ASEIK 261_ ISKSN 266_ NQNVE 271_ PHKRL 276_ LKVRS 281_ MVEGL 286_ GGPLG 291_ HAGEE 296_ SEVDN 301_ DVDSP 306_ GSLRR 311_ GLRST 316_ SYRRA 321_ VVSGF 326_ DFDSP 331_ TSSKK 336_ KNRMS 341_ QPVLK 346_ VVMED 351_ KEKFS 356_ SLGRI 361_ KKKML 366_ KGQGT 371_ FDGEE 376_ NAVLY 381_ QNYKE 386_ KALDI 391_ DSDEE 396_ SEPKE 401_ QKSDE 406_ KIVIH 411_ HKPLR 416_ STWSQ 421_ LSAVK 426_ RKGLS 431_ QTVSQ 436_ EERKR 441_ QEAIF 446_ EVISS 451_ EHSYL 456_ LSLEI 461_ LIRMF 466_ KNSKE 471_ LSDTM 476_ TKTER 481_ HHLFS 486_ NITDV 491_ CEASK 496_ KFFIE 501_ LEARH 506_ QNNIF 511_ IDDIS 516_ DIVEK 521_ HTAST 526_ FDPYV 531_ KYCTN 536_ EVYQQ 541_ RTLQK 546_ LLATN 551_ PSFKE 556_ VLSRI 561_ ESHED 566_ CRNLP 571_ MISFL 576_ ILPMQ 581_ RVTRL 586_ PLLMD 591_ TICQK 596_ TPKDS 601_ PKYEV 606_ CKRAL 611_ KEVSK 616_ LVRLC 621_ NEGAR 626_ KMERT 631_ EMMYT 636_ INSQL 641_ EFKIK 646_ PFPLV 651_ SSSRW 656_ LVKRG 661_ ELTAY 666_ VEDTV 671_ LFSRR 676_ TSKQQ 681_ VYFFL 686_ FNDVL 691_ IITKK 696_ KSEES 701_ YNVND 706_ YSLRD 711_ QLLVE 716_ SCDNE 721_ ELNSS 726_ PGKNS 731_ STMLY 736_ SRQSS 741_ ASHLF 746_ TLTVL 751_ SNHAN 756_ EKVEM 761_ LLGAE 766_ TQSER 771_ ARWIT 776_ ALGHS 781_ SGKPP 786_ ADRTS 791_ LTQVE 796_ IVRSF 801_ TAKQP 806_ DELSL 811_ QVADV 816_ VLIYQ 821_ RVSDG 826_ WYEGE 831_ RLRDG 836_ ERGWF 841_ PMECA 846_ KEITC 851_ QATID 856_ KNVER 861_ MGRLL 866_GLETN
1: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry