SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
1_MLWLF 6_ QSLLF 11_ VFCFG 16_ PGNVV 21_ SQSSL 26_ TPLMV 31_ NGILG 36_ ESVTL 41_ PLEFP 46_ AGEKV 51_ NFITW 56_ LFNET 61_ SLAFI 66_ VPHET 71_ KSPEI 76_ HVTNP 81_ KQGKR 86_ LNFTQ 91_ SYSLQ 96_ LSNLK 101_ MEDTG 106_ SYRAQ 111_ ISTKT 116_ SAKLS 121_ SYTLR 126_ ILRQL 131_ RNIQV 136_ TNHSQ 141_ LFQNM 146_ TCELH 151_ LTCSV 156_ EDADD 161_ NVSFR 166_ WEALG 171_ NTLSS 176_ QPNLT 181_ VSWDP 186_ RISSE 191_ QDYTC 196_ IAENA 201_ VSNLS 206_ FSVSA 211_ QKLCE 216_ DVKIQ 221_ YTDTK 226_ MILFM 231_ VSGIC 236_ IVFGF 241_ IILLL 246_ LVLRK 251_ RRDSL 256_ SLSTQ 261_ RTQGP 266_ AESAR 271_ NLEYV 276_ SVSPT 281_ NNTVY 286_ ASVTH 291_ SNRET 296_ EIWTP 301_ RENDT 306_ ITIYS 311_ TINHS 316_ KESKP 321_ TFSRA 326_TALDN
1: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:16920955, PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity)