Ankyrin repeat and SOCS box protein 9 (ASB-9)
1_MDGKQ 6_ GGMDG 11_ SKPAG 16_ PRDFP 21_ GIRLL 26_ SNPLM 31_ GDAVS 36_ DWSPM 41_ HEAAI 46_ HGHQL 51_ SLRNL 56_ ISQGW 61_ AVNII 66_ TADHV 71_ SPLHE 76_ ACLGG 81_ HLSCV 86_ KILLK 91_ HGAQV 96_ NGVTA 101_ DWHTP 106_ LFNAC 111_ VSGSW 116_ DCVNL 121_ LLQHG 126_ ASVQP 131_ ESDLA 136_ SPIHE 141_ AARRG 146_ HVECV 151_ NSLIA 156_ YGGNI 161_ DHKIS 166_ HLGTP 171_ LYLAC 176_ ENQQR 181_ ACVKK 186_ LLESG 191_ ADVNQ 196_ GKGQD 201_ SPLHA 206_ VARTA 211_ SEELA 216_ CLLMD 221_ FGADT 226_ QAKNA 231_ EGKRP 236_ VELVP 241_ PESPL 246_ AQLFL 251_ EREGP 256_ PSLMQ 261_ LCRLR 266_ IRKCF 271_ GIQQH 276_ HKITK 281_ LVLPE 286_DLKQF
1: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465)
2: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1