Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4)
1_MVVDF 6_ WTWEQ 11_ TFQEL 16_ IQEAK 21_ PRATW 26_ TLKLD 31_ GNLQL 36_ DCLAQ 41_ GWKQY 46_ QQRAF 51_ GWFRC 56_ SSCQR 61_ SWASA 66_ QVQIL 71_ CHTYW 76_ EHWTS 81_ QGQVR 86_ MRLFG 91_ QRCQK 96_ CSWSQ 101_ YEMPE 106_ FSSDS 111_ TMRIL 116_ SNLVQ 121_ HILKK 126_ YYGNG 131_ TRKSP 136_ EMPVI 141_ LEVSL 146_ EGSHD 151_ TANCE 156_ ACTLG 161_ ICGQG 166_ LKSCM 171_ TKPSK 176_ SLLPH 181_ LKTGN 186_ SSPGI 191_ GAVYL 196_ ANQAK 201_ NQSAE 206_ AKEAK 211_ GSGYE 216_ KLGPS 221_ RDPDP 226_ LNICV 231_ FILLL 236_ VFIVV 241_KCFTS
1: Chaperone protein that facilitates the trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs) (PubMed:18836069). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (PubMed:33113352). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1 (PubMed:39798334)