PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1)
1_MAQEK 6_ MELDL 11_ ELPPG 16_ TGGSP 21_ AEGGG 26_ SGGGG 31_ GLRRS 36_ NSAPL 41_ IHGLS 46_ DTSPV 51_ FQAEA 56_ PSARR 61_ NSTTF 66_ PSRHG 71_ LLLPA 76_ SPVRM 81_ HSSRL 86_ HQIKQ 91_ EEGMD 96_ LINRE 101_ TVHER 106_ EVQTA 111_ MQISH 116_ SWEES 121_ FSLSD 126_ NDVEK 131_ SASPK 136_ RIDFI 141_ PVSPA 146_ PSPTR 151_ GIGKQ 156_ CFSPS 161_ LQSFV 166_ SSNGL 171_ PPSPI 176_ PSPTT 181_ RFTTR 186_ RSQSP 191_ INCIR 196_ PSVLG 201_ PLKRK 206_ CEMET 211_ EYQPK 216_ RFFQG 221_ ITNML 226_ SSDVA 231_ QLSDP 236_ GVCVS 241_ SDTLD 246_ GNSSS 251_ AGSSC 256_ NSPAK 261_ VSTTT 266_ DSPVS 271_ PAQAA 276_ SPFIP 281_LDELS
1: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758)