Ras-related protein Rab-3C
1_MRHEA 6_ PMQMA 11_ SAQDA 16_ RYGQK 21_ DSSDQ 26_ NFDYM 31_ FKLLI 36_ IGNSS 41_ VGKTS 46_ FLFRY 51_ ADDSF 56_ TSAFV 61_ STVGI 66_ DFKVK 71_ TVFKN 76_ EKRIK 81_ LQIWD 86_ TAGQE 91_ RYRTI 96_ TTAYY 101_ RGAMG 106_ FILMY 111_ DITNE 116_ ESFNA 121_ VQDWS 126_ TQIKT 131_ YSWDN 136_ AQVIL 141_ VGNKC 146_ DMEDE 151_ RVIST 156_ ERGQH 161_ LGEQL 166_ GFEFF 171_ ETSAK 176_ DNINV 181_ KQTFE 186_ RLVDI 191_ ICDKM 196_ SESLE 201_ TDPAI 206_ TAAKQ 211_ NTRLK 216_ ETPPP 221_PQPNC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion