Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog)
1_MTGLY 6_ ELVWR 11_ VLHAL 16_ LCLHR 21_ TLTSW 26_ LRVRF 31_ GTWNW 36_ IWRRC 41_ CRAAS 46_ AAVLA 51_ PLGFT 56_ LRKPP 61_ AVGRN 66_ RRHHR 71_ HPRGG 76_ SCLAA 81_ AHHRM 86_ RWRAD 91_ GRSLE 96_ KLPVH 101_ MGLVI 106_ TEVEQ 111_ EPSFS 116_ DIASL 121_ VVWCM 126_ AVGIS 131_ YISVY 136_ DHQGI 141_ FKRNN 146_ SRLMD 151_ EILKQ 156_ QQELL 161_ GLDCS 166_ KYSPE 171_ FANSN 176_ DKDDQ 181_ VLNCH 186_ LAVKV 191_ LSPED 196_ GKADI 201_ VRAAQ 206_ DFCQL 211_ VAQKQ 216_ KRPTD 221_ LDVDT 226_ LASLL 231_ SSNGC 236_ PDPDL 241_ VLKFG 246_ PVDST 251_ LGFLP 256_ WHIRL 261_ TEIVS 266_ LPSHL 271_ NISYE 276_ DFFSA 281_ LRQYA 286_ACEQR
1: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300)