Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)
1_MEADI 6_ ITNLR 11_ CRLKE 16_ AEEER 21_ LKAAQ 26_ YGLQL 31_ VESQN 36_ ELQNQ 41_ LDKCR 46_ NEMMT 51_ MTESY 56_ EQEKY 61_ TLQRE 66_ VELKS 71_ RMLES 76_ LSCEC 81_ EAIKQ 86_ QQKMH 91_ LEKLE 96_ EQLSR 101_ SHGQE 106_ VNELK 111_ TKIEK 116_ LKVEL 121_ DEARL 126_ SEKQL 131_ KHQVD 136_ HQKEL 141_ LSCKS 146_ EELRV 151_ MSERV 156_ QESMS 161_ SEMLA 166_ LQIEL 171_ TEMES 176_ MKTTL 181_ KEEVN 186_ ELQYR 191_ QEQLE 196_ LLITN 201_ LMRQV 206_ DRLKE 211_ EKEER 216_ EKEAV 221_ SYYNA 226_ LEKAR 231_ VANQD 236_ LQVQL 241_ DQALQ 246_ QALDP 251_ NSKGN 256_ SLFAE 261_ VEDRR 266_ AAMER 271_ QLISM 276_ KVKYQ 281_ SLKKQ 286_ NVFNR 291_ EQMQR 296_ MKLQI 301_ ATLLQ 306_ MKGSQ 311_ TEFEQ 316_ QERLL 321_ AMLEQ 326_ KNGEI 331_ KHLLG 336_ EIRNL 341_ EKFKN 346_ LYDSM 351_ ESKPS 356_ VDSGT 361_ LEDNT 366_ YYTDL 371_ LQMKL 376_ DNLNK 381_ EIEST 386_ KGELS 391_ IQRMK 396_ ALFES 401_ QRALD 406_ IERKL 411_ FANER 416_ CLQLS 421_ ESENM 426_ KLRAK 431_ LDELK 436_ LKYEP 441_ EETVE 446_ VPVLK 451_ KRREV 456_ LPVDI 461_ TTAKD 466_ ACVNN 471_ SALGG 476_ EVYRL 481_ PPQKE 486_ ETQSC 491_ PNSLE 496_ DNNLQ 501_ LEKSV 506_ SIYTP 511_ VVSLS 516_ PHKNL 521_ PVDMQ 526_ LKKEK 531_ KCVKL 536_ IGVPA 541_ DAEAL 546_ SERSG 551_ NTPNS 556_ PRLAA 561_ ESKLQ 566_ TEVKE 571_ GKETS 576_ SKLEK 581_ ETCKK 586_ LHPIL 591_ YVSSK 596_STPET
1: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100)