Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein)
1_MAAVA 6_ TCGSV 11_ AASTG 16_ SAVAT 21_ ASKSN 26_ VTSFQ 31_ RRGPR 36_ ASVTN 41_ DSGPR 46_ LVSIA 51_ GTRPS 56_ VRNGQ 61_ LLVST 66_ GLPAL 71_ DQLLG 76_ GGLAV 81_ GTVLL 86_ IEEDK 91_ YNIYS 96_ PLLFK 101_ YFLAE 106_ GIVNG 111_ HTLLV 116_ ASAKE 121_ DPANI 126_ LQELP 131_ APLLD 136_ DKCKK 141_ EFDED 146_ VYNHK 151_ TPESN 156_ IKMKI 161_ AWRYQ 166_ LLPKM 171_ EIGPV 176_ SSSRF 181_ GHYYD 186_ ASKRM 191_ PQELI 196_ EASNW 201_ HGFFL 206_ PEKIS 211_ STLKV 216_ EPCSL 221_ TPGYT 226_ KLLQF 231_ IQNII 236_ YEEGF 241_ DGSNP 246_ QKKQR 251_ NILRI 256_ GIQNL 261_ GSPLW 266_ GDDIC 271_ CAENG 276_ GNSHS 281_ LTKFL 286_ YVLRG 291_ LLRTS 296_ LSACI 301_ ITMPT 306_ HLIQN 311_ KAIIA 316_ RVTTL 321_ SDVVV 326_ GLESF 331_ IGSER 336_ ETNPL 341_ YKDYH 346_ GLIHI 351_ RQIPR 356_ LNNLI 361_ CDESD 366_ VKDLA 371_ FKLKR 376_ KLFTI 381_ ERLHL 386_ PPDLS 391_ DTVSR 396_ SSKMD 401_ LAESA 406_ KRLGP 411_ GCGMM 416_AGGKK
1: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244)