Nucleoporin SEH1 (GATOR complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
1_MFVAR 6_ SIAAD 11_ HKDLI 16_ HDVSF 21_ DFHGR 26_ RMATC 31_ SSDQS 36_ VKVWD 41_ KSESG 46_ DWHCT 51_ ASWKT 56_ HSGSV 61_ WRVTW 66_ AHPEF 71_ GQVLA 76_ SCSFD 81_ RTAAV 86_ WEEIV 91_ GESND 96_ KLRGQ 101_ SHWVK 106_ RTTLV 111_ DSRTS 116_ VTDVK 121_ FAPKH 126_ MGLML 131_ ATCSA 136_ DGIVR 141_ IYEAP 146_ DVMNL 151_ SQWSL 156_ QHEIS 161_ CKLSC 166_ SCISW 171_ NPSSS 176_ RAHSP 181_ MIAVG 186_ SDDSS 191_ PNAMA 196_ KVQIF 201_ EYNEN 206_ TRKYA 211_ KAETL 216_ MTVTD 221_ PVHDI 226_ AFAPN 231_ LGRSF 236_ HILAI 241_ ATKDV 246_ RIFTL 251_ KPVRK 256_ ELTSS 261_ GGPTK 266_ FEIHI 271_ VAQFD 276_ NHNSQ 281_ VWRVS 286_ WNITG 291_ TVLAS 296_ SGDDG 301_ CVRLW 306_ KANYM 311_ DNWKC 316_ TGILK 321_ GNGSP 326_ VNGSS 331_ QQGTS 336_ NPSLG 341_ STIPS 346_ LQNSL 351_NGSSA
1: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900)
2: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510)