Mitochondrial assembly of ribosomal large subunit protein 1
1_MGPGG 6_ RVARL 11_ LAPLM 16_ WRRAV 21_ SSVAG 26_ SAVGA 31_ EPGLR 36_ LLAVQ 41_ RLPVG 46_ AAFCR 51_ ACQTP 56_ NFVRG 61_ LHSEP 66_ GLEER 71_ AEGTV 76_ NEGRP 81_ ESDAA 86_ DHTGP 91_ KFDID 96_ MMVSL 101_ LRQEN 106_ ARDIC 111_ VIQVP 116_ PEMRY 121_ TDYFV 126_ IVSGT 131_ STRHL 136_ HAMAF 141_ YVVKM 146_ YKHLK 151_ CKRDP 156_ HVKIE 161_ GKDTD 166_ DWLCV 171_ DFGSM 176_ VIHLM 181_ LPETR 186_ EIYEL 191_ EKLWT 196_ LRSYD 201_ DQLAQ 206_ IAPET 211_ VPEDF 216_ ILGIE 221_ DDTSS 226_VTPVE
1: Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable)