E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)
1_MGAQL 6_ CFEAN 11_ AKAPR 16_ EALRF 21_ HAEAK 26_ GAQVR 31_ LDTRG 36_ CIAHR 41_ RTTFH 46_ DGIVF 51_ SQRPV 56_ RLGER 61_ VALRV 66_ LREES 71_ GWCGG 76_ LRVGF 81_ TRLDP 86_ ACVSV 91_ PSLPP 96_ FLCPD 101_ LEEQS 106_ PTWAA 111_ VLPEG 116_ CALTG 121_ DLVRF 126_ WVDRR 131_ GCLFA 136_ KVNAG 141_ CRLLL 146_ REGVP 151_ VGAPL 156_ WAVMD 161_ VYGTT 166_ KAIEL 171_ LDPTA 176_ SRLPT 181_ PMPWD 186_ LSNKA 191_ VPEPK 196_ ATPGE 201_ ECAIC 206_ FYHAA 211_ NTRLV 216_ PCGHT 221_ YFCRY 226_ CAWRV 231_ FSDTA 236_ KCPVC 241_ RWQIE 246_ AVAPA 251_ QGPPA 256_LRVEE
1: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (PubMed:38667302)