THAP domain-containing protein 11
1_MPGFT 6_ CCVPG 11_ CYNNS 16_ HRDKA 21_ LHFYT 26_ FPKDA 31_ ELRRL 36_ WLKNV 41_ SRAGV 46_ SGCFS 51_ TFQPT 56_ TGHRL 61_ CSVHF 66_ QGGRK 71_ TYTVR 76_ VPTIF 81_ PLRGV 86_ NERKV 91_ ARRPA 96_ GAAAA 101_ RRRQQ 106_ QQQQQ 111_ QQQQQ 116_ QQQQQ 121_ QQQQQ 126_ QQQQQ 131_ QQSSP 136_ SASTA 141_ QTAQL 146_ QPNLV 151_ SASAA 156_ VLLTL 161_ QATVD 166_ SSQAP 171_ GSVQP 176_ APITP 181_ TGEDV 186_ KPIDL 191_ TVQVE 196_ FAAAE 201_ GAAAA 206_ AAASE 211_ LQAAT 216_ AGLEA 221_ AECPM 226_ GPQLV 231_ VVGEE 236_ GFPDT 241_ GSDHS 246_ YSLSS 251_ GTTEE 256_ ELLRK 261_ LNEQR 266_ DILAL 271_ MEVKM 276_ KEMKG 281_ SIRHL 286_ RLTEA 291_ KLREE 296_ LREKD 301_ RLLAM 306_AVIRK
1: Transcription factor, which has both transcriptional activation and repression activities (PubMed:31905202). Also modulates chromatin accessibility (PubMed:38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed:28449119, PubMed:31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed:31905202)