Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase)
1_MAGAA 6_ AESGR 11_ ELWTF 16_ AGSRD 21_ PSAPR 26_ LAYGY 31_ GPGSL 36_ RELRA 41_ REFSR 46_ LAGTV 51_ YLDHA 56_ GATLF 61_ SQSQL 66_ ESFTS 71_ DLMEN 76_ TYGNP 81_ HSQNI 86_ SSKLT 91_ HDTVE 96_ QVRYR 101_ ILAHF 106_ HTTAE 111_ DYTVI 116_ FTAGS 121_ TAALK 126_ LVAEA 131_ FPWVS 136_ QGPES 141_ SGSRF 146_ CYLTD 151_ SHTSV 156_ VGMRN 161_ VTMAI 166_ NVIST 171_ PVRPE 176_ DLWSA 181_ EERSA 186_ SASNP 191_ DCQLP 196_ HLFCY 201_ PAQSN 206_ FSGVR 211_ YPLSW 216_ IEEVK 221_ SGRLH 226_ PVSTP 231_ GKWFV 236_ LLDAA 241_ SYVST 246_ SPLDL 251_ SAHQA 256_ DFVPI 261_ SFYKI 266_ FGFPT 271_ GLGAL 276_ LVHNR 281_ AAPLL 286_ RKTYF 291_ GGGTA 296_ SAYLA 301_ GEDFY 306_ IPRQS 311_ VAQRF 316_ EDGTI 321_ SFLDV 326_ IALKH 331_ GFDTL 336_ ERLTG 341_ GMENI 346_ KQHTF 351_ TLAQY 356_ TYVAL 361_ SSLQY 366_ PNGAP 371_ VVRIY 376_ SDSEF 381_ SSPEV 386_ QGPII 391_ NFNVL 396_ DDKGN 401_ IIGYS 406_ QVDKM 411_ ASLYN 416_ IHLRT 421_ GCFCN 426_ TGACQ 431_ RHLGI 436_ SNEMV 441_ RKHFQ 446_ AGHVC 451_ GDNMD 456_ LIDGQ 461_ PTGSV 466_ RISFG 471_ YMSTL 476_ DDVQA 481_ FLRFI 486_ IDTRL 491_ HSSGD 496_ WPVPQ 501_ AHADT 506_ GETGA 511_ PSADS 516_ QADVI 521_ PAVMG 526_ RRSLS 531_ PQEDA 536_ LTGSR 541_ VWNNS 546_ STVNA 551_ VPVAP 556_ PVCDV 561_ ARTQP 566_ TPSEK 571_ AAGVL 576_ EGALG 581_ PHVVT 586_ NLYLY 591_ PIKSC 596_ AAFEV 601_ TRWPV 606_ GNQGL 611_ LYDRS 616_ WMVVN 621_ HNGVC 626_ LSQKQ 631_ EPRLC 636_ LIQPF 641_ IDLRQ 646_ RIMVI 651_ KAKGM 656_ EPIEV 661_ PLEEN 666_ SERTQ 671_ IRQSR 676_ VCADR 681_ VSTYD 686_ CGEKI 691_ SSWLS 696_ TFFGR 701_ PCHLI 706_ KQSSN 711_ SQRNA 716_ KKKHG 721_ KDQLP 726_ GTMAT 731_ LSLVN 736_ EAQYL 741_ LINTS 746_ SILEL 751_ HRQLN 756_ TSDEN 761_ GKEEL 766_ FSLKD 771_ LSLRF 776_ RANII 781_ INGKR 786_ AFEEE 791_ KWDEI 796_ SIGSL 801_ RFQVL 806_ GPCHR 811_ CQMIC 816_ IDQQT 821_ GQRNQ 826_ HVFQK 831_ LSESR 836_ ETKVN 841_ FGMYL 846_ MHASL 851_ DLSSP 856_ CFLSV 861_ GSQVL 866_ PVLKE 871_ NVEGH 876_ DLPAS 881_EKHQD
1: Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608)