E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
1_MPGEE 6_ EERAF 11_ LVARE 16_ ELASA 21_ LRRDS 26_ GQAFS 31_ LEQLR 36_ PLLAS 41_ SLPLA 46_ ARYLQ 51_ LDAAR 56_ LVRCN 61_ AHGEP 66_ RNYLN 71_ TLSTA 76_ LNILE 81_ KYGRN 86_ LLSPQ 91_ RPRYW 96_ RGVKF 101_ NNPVF 106_ RSTVD 111_ AVQGG 116_ RDVLR 121_ LYGYT 126_ EEQPD 131_ GLSFP 136_ EGQEE 141_ PDEHQ 146_ VATVT 151_ LEVLL 156_ LRTEL 161_ SLLLQ 166_ NTHPR 171_ QQALE 176_ QLLED 181_ KVEDD 186_ MLQLS 191_ EFDPL 196_ LREIA 201_ PGPLT 206_ TPSVP 211_ GSTPG 216_ PCFLC 221_ GSAPG 226_ TLHCP 231_ SCKQA 236_ LCPAC 241_ DHLFH 246_ GHPSR 251_ AHHLR 256_ QTLPG 261_ VLQGT 266_ HLSPS 271_ LPASA 276_ QPRPQ 281_ STSLL 286_ ALGDS 291_ SLSSP 296_ NPASA 301_ HLPWH 306_ CAACA 311_ MLNEP 316_ WAVLC 321_ VACDR 326_ PRGCK 331_ GLGLG 336_ TEGPQ 341_ GTGGL 346_ EPDLA 351_ RGRWA 356_ CQSCT 361_ FENEA 366_ AAVLC 371_ SICER 376_ PRLAQ 381_ PPSLV 386_ VDSRD 391_ AGICL 396_ QPLQQ 401_ GDALL 406_ ASAQS 411_ QVWYC 416_ IHCTF 421_ CNSSP 426_ GWVCV 431_ MCNRT 436_ SSPIP 441_ AQHAP 446_ RPYAS 451_ SLEKG 456_ PPKPG 461_ PPRRL 466_ SAPLP 471_ SSCGD 476_ PEKQR 481_ QDKMR 486_ EEGLQ 491_ LVSMI 496_ REGEA 501_ AGACP 506_ EEIFS 511_ ALQYS 516_ GTEVP 521_ LQWLR 526_ SELPY 531_ VLEMV 536_ AELAG 541_ QQDPG 546_ LGAFS 551_ CQEAR 556_ RAWLD 561_ RHGNL 566_ DEAVE 571_ ECVRT 576_ RRRKV 581_ QELQS 586_ LGFGP 591_ EEGSL 596_ QALFQ 601_ HGGDV 606_ SRALT 611_ ELQRQ 616_ RLEPF 621_ RQRLW 626_ DSGPE 631_ PTPSW 636_ DGPDK 641_ QSLVR 646_ RLLAV 651_ YALPS 656_ WGRAE 661_ LALSL 666_ LQETP 671_ RNYEL 676_ GDVVE 681_ AVRHS 686_ QDRAF 691_ LRRLL 696_ AQECA 701_ VCGWA 706_ LPHNR 711_ MQALT 716_ SCECT 721_ ICPDC 726_ FRQHF 731_ TIALK 736_ EKHIT 741_ DMVCP 746_ ACGRP 751_ DLTDD 756_ TQLLS 761_ YFSTL 766_ DIQLR 771_ ESLEP 776_ DAYAL 781_ FHKKL 786_ TEGVL 791_ MRDPK 796_ FLWCA 801_ QCSFG 806_ FIYER 811_ EQLEA 816_ TCPQC 821_ HQTFC 826_ VRCKR 831_ QWEEQ 836_ HRGRS 841_ CEDFQ 846_ NWKRM 851_ NDPEY 856_ QAQGL 861_ AMYLQ 866_ ENGID 871_ CPKCK 876_ FSYAL 881_ ARGGC 886_ MHFHC 891_ TQCRH 896_ QFCSG 901_ CYNAF 906_ YAKNK 911_ CPEPN 916_ CRVKK 921_ SLHGH 926_ HPRDC 931_ LFYLR 936_ DWTAL 941_ RLQKL 946_ LQDNN 951_ VMFNT 956_ EPPAG 961_ ARAVP 966_ GGGCR 971_ VIEQK 976_ EVPNG 981_ LRDEA 986_ CGKET 991_ PAGYA 996_ GLCQA 1001_ HYKEY 1006_ LVSLI 1011_ NAHSL 1016_ DPATL 1021_ YEVEE 1026_ LETAT 1031_ ERYLH 1036_ VRPQP 1041_ LAGED 1046_ PPAYQ 1051_ ARLLQ 1056_ KLTEE 1061_ VPLGQ 1066_SIPRR
1: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998)