E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
1_MGSVL 6_ STDSG 11_ KSAPA 16_ SATAR 21_ ALERR 26_ RDPEL 31_ PVTSF 36_ DCAVC 41_ LEVLH 46_ QPVRT 51_ RCGHV 56_ FCRSC 61_ IATSL 66_ KNNKW 71_ TCPYC 76_ RAYLP 81_ SEGVP 86_ ATDVA 91_ KRMKS 96_ EYKNC 101_ AECDT 106_ LVCLS 111_ EMRAH 116_ IRTCQ 121_ KYIDK 126_ YGPLQ 131_ ELEET 136_ AARCV 141_ CPFCQ 146_ RELYE 151_ DSLLD 156_ HCITH 161_ HRSER 166_ RPVFC 171_ PLCRL 176_ IPDEN 181_ PSSFS 186_ GSLIR 191_ HLQVS 196_ HTLFY 201_ DDFID 206_ FNIIE 211_ EALIR 216_ RVLDR 221_ SLLEY 226_VNHSN
1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:25591766, PubMed:26027934, PubMed:26471729, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525)