Mitochondrial potassium channel (MITOK) (Coiled-coil domain-containing protein 51)
1_MMGRS 6_ PGFAM 11_ QHIVG 16_ VPHVL 21_ VRRGL 26_ LGRDL 31_ FMTRT 36_ LCSPG 41_ PSQPG 46_ EKRPE 51_ EVALG 56_ LHHRL 61_ PALGR 66_ ALGHS 71_ IQQRA 76_ TSTAK 81_ TWWDR 86_ YEEFV 91_ GLNEV 96_ REAQG 101_ KVTEA 106_ EKVFM 111_ VARGL 116_ VREAR 121_ EDLEV 126_ HQAKL 131_ KEVRD 136_ RLDRV 141_ SREDS 146_ QYLEL 151_ ATLEH 156_ RMLQE 161_ EKRLR 166_ TAYLR 171_ AEDSE 176_ REKFS 181_ LFSAA 186_ VRESH 191_ EKERT 196_ RAERT 201_ KNWSL 206_ IGSVL 211_ GALIG 216_ VAGST 221_ YVNRV 226_ RLQEL 231_ KALLL 236_ EAQKG 241_ PVSLQ 246_ EAIRE 251_ QASSY 256_ SRQQR 261_ DLHNL 266_ MVDLR 271_ GLVHA 276_ AGPGQ 281_ DSGSQ 286_ AGSPP 291_ TRDRD 296_ VDVLS 301_ AALKE 306_ QLSHS 311_ RQVHS 316_ CLEGL 321_ REQLD 326_ GLEKT 331_ CSQMA 336_ GVVQL 341_ VKSAA 346_ HPGLV 351_ EPADG 356_ AMPSF 361_ LLEQG 366_ SMILA 371_ LSDTE 376_ QRLEA 381_ QVNRN 386_ TIYST 391_ LVTCV 396_ TFVAT 401_ LPVLY 406_MLFKA
1: Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016)