Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34)
1_MATRA 6_ QPGPL 11_ SQAGS 16_ AGVAA 21_ LATVG 26_ VASGP 31_ GPGRP 36_ GPLQD 41_ ETLGV 46_ ASVPS 51_ QWRAV 56_ QGIRW 61_ ETKSC 66_ QTASI 71_ ATASA 76_ SAQAR 81_ NHVDA 86_ QVQTE 91_ APVPV 96_ SVQPP 101_ SQYDI 106_ PRLAA 111_ FLRRV 116_ EAMVI 121_ RELNK 126_ NWQSH 131_ AFDGF 136_ EVNWT 141_ EQQQM 146_ VSCLY 151_ TLGYP 156_ PAQAQ 161_ GLHVT 166_ SISWN 171_ STGSV 176_ VACAY 181_ GRLDH 186_ GDWST 191_ LKSFV 196_ CAWNL 201_ DRRDL 206_ RPQQP 211_ SAVVE 216_ VPSAV 221_ LCLAF 226_ HPTQP 231_ SHVAG 236_ GLYSG 241_ EVLVW 246_ DLSRL 251_ EDPLL 256_ WRTGL 261_ TDDTH 266_ TDPVS 271_ QVVWL 276_ PEPGH 281_ SHRFQ 286_ VLSVA 291_ TDGKV 296_ LLWQG 301_ IGVGQ 306_ LQLTE 311_ GFALV 316_ MQQLP 321_ RSTKL 326_ KKHPR 331_ GETEV 336_ GATAV 341_ AFSSF 346_ DPRLF 351_ ILGTE 356_ GGFPL 361_ KCSLA 366_ AGEAA 371_ LTRMP 376_ SSVPL 381_ RAPAQ 386_ FTFSP 391_ HGGPI 396_ YSVSC 401_ SPFHR 406_ NLFLS 411_ AGTDG 416_ HVHLY 421_ SMLQA 426_ PPLTS 431_ LQLSL 436_ KYLFA 441_ VRWSP 446_ VRPLV 451_ FAAAS 456_ GKGDV 461_ QLFDL 466_ QKSSQ 471_ KPTVL 476_ IKQTQ 481_ DESPV 486_ YCLEF 491_ NSQQT 496_ QLLAA 501_ GDAQG 506_ TVKVW 511_ QLSTE 516_ FTEQG 521_ PREAE 526_ DLDCL 531_AAEVA
1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:25205765, PubMed:29742051). DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:29742051, PubMed:30320547, PubMed:30649997). Required also to maintain a functional transition zone (PubMed:30320547)
2: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation