DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)
1_MAARC 6_ STRWL 11_ LVVVG 16_ TPRLP 21_ AISGR 26_ GARPP 31_ REGVV 36_ GAWLS 41_ RKLSV 46_ PAFAS 51_ SLTSC 56_ GPRAL 61_ LTLRP 66_ GVSLT 71_ GTKHN 76_ PFICT 81_ ASFHT 86_ SAPLA 91_ KEDYY 96_ QILGV 101_ PRNAS 106_ QKEIK 111_ KAYYQ 116_ LAKKY 121_ HPDTN 126_ KDDPK 131_ AKEKF 136_ SQLAE 141_ AYEVL 146_ SDEVK 151_ RKQYD 156_ AYGSA 161_ GFDPG 166_ ASGSQ 171_ HSYWK 176_ GGPTV 181_ DPEEL 186_ FRKIF 191_ GEFSS 196_ SSFGD 201_ FQTVF 206_ DQPQE 211_ YFMEL 216_ TFNQA 221_ AKGVN 226_ KEFTV 231_ NIMDT 236_ CERCN 241_ GKGNE 246_ PGTKV 251_ QHCHY 256_ CGGSG 261_ METIN 266_ TGPFV 271_ MRSTC 276_ RRCGG 281_ RGSII 286_ ISPCV 291_ VCRGA 296_ GQAKQ 301_ KKRVM 306_ IPVPA 311_ GVEDG 316_ QTVRM 321_ PVGKR 326_ EIFIT 331_ FRVQK 336_ SPVFR 341_ RDGAD 346_ IHSDL 351_ FISIA 356_ QALLG 361_ GTARA 366_ QGLYE 371_ TINVT 376_ IPPGT 381_ QTDQK 386_ IRMGG 391_ KGIPR 396_ INSYG 401_ YGDHY 406_ IHIKI 411_ RVPKR 416_ LTSRQ 421_ QSLIL 426_ SYAED 431_ ETDVE 436_ GTVNG 441_ VTLTS 446_ SGGST 451_ MDSSA 456_ GSKAR 461_ REAGE 466_ DEEGF 471_LSKLK
1: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway