Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)
1_MDKDS 6_ QGLLD 11_ SSLMA 16_ SGTAS 21_ RSEDE 26_ ESLAG 31_ QKRAS 36_ SQALG 41_ TIPKR 46_ RSSSR 51_ FIKRK 56_ KFDDE 61_ LVESS 66_ LAKSS 71_ TRAKG 76_ ASGVE 81_ PGRCS 86_ GSEPS 91_ SSEKK 96_ KVSKA 101_ PSTPV 106_ PPSPA 111_ PAPGL 116_ TKRVK 121_ KSKQP 126_ LQVTK 131_ DLGRW 136_ KPADD 141_ LLLIN 146_ AVLQT 151_ NDLTS 156_ VHLGV 161_ KFSCR 166_ FTLRE 171_ VQERW 176_ YALLY 181_ DPVIS 186_ KLACQ 191_ AMRQL 196_ HPEAI 201_ AAIQS 206_ KALFS 211_ KAEEQ 216_ LLSKV 221_ GSTSQ 226_ PTLET 231_ FQDLL 236_ HRHPD 241_ AFYLA 246_ RTAKA 251_ LQAHW 256_ QLMKQ 261_ YYLLE 266_ DQTVQ 271_ PLPKG 276_ DQVLN 281_ FSDAE 286_ DLIDD 291_ SKLKD 296_ MRDEV 301_ LEHEL 306_ MVADR 311_ RQKRE 316_ IRQLE 321_ QELHK 326_ WQVLV 331_ DSITG 336_ MSSPD 341_ FDNQT 346_ LAVLR 351_ GRMVR 356_ YLMRS 361_ REITL 366_ GRATK 371_ DNQID 376_ VDLSL 381_ EGPAW 386_ KISRK 391_ QGVIK 396_ LKNNG 401_ DFFIA 406_ NEGRR 411_ PIYID 416_ GRPVL 421_ CGSKW 426_ RLSNN 431_ SVVEI 436_ ASLRF 441_ VFLIN 446_ QDLIA 451_ LIRAE 456_AAKIT
1: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491)