GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3)
1_MGGFQ 6_ RGKYG 11_ TMAEG 16_ RSEDN 21_ LSATP 26_ PALRI 31_ ILVGK 36_ TGCGK 41_ SATGN 46_ SILGQ 51_ PVFES 56_ KLRAQ 61_ SVTRT 66_ CQVKT 71_ GTWNG 76_ RKVLV 81_ VDTPS 86_ IFESQ 91_ ADTQE 96_ LYKNI 101_ GDCYL 106_ LSAPG 111_ PHVLL 116_ LVIQL 121_ GRFTA 126_ QDTVA 131_ IRKVK 136_ EVFGT 141_ GAMRH 146_ VVILF 151_ THKED 156_ LGGQA 161_ LDDYV 166_ ANTDN 171_ CSLKD 176_ LVREC 181_ ERRYC 186_ AFNNW 191_ GSVEE 196_ QRQQQ 201_ AELLA 206_ VIERL 211_ GRERE 216_ GSFHS 221_ NDLFL 226_ DAQLL 231_ QRTGA 236_ GACQE 241_ DYRQY 246_ QAKVE 251_ WQVEK 256_ HKQEL 261_ RENES 266_ NWAYK 271_ ALLRV 276_ KHLML 281_ LHYEI 286_ FVFLL 291_ LCSIL 296_ FFIIF 301_LFIFH
1: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity)